DegronMD

Uniprot ID: O15085

Source protein: Rho guanine nucleotide exchange factor 11

Source gene: ARHGEF11

Class: DEG_SCF_FBW7_1

Location: 1234:1239

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 80.1667

COIL: 0.9533

CONS_SCORE: 0.4403

DSS_SCORE: 0.7423

HELIX: 0.0182

FCONS_SCORE: 1.2405

RIG_SCORE: 0.6604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1237H	TCGA-A8-A085	BRCA	TCGA	LTPTPS	DEG_SCF_FBW7_1	0.7313
p.E1246D	TCGA-AC-A23H	BRCA	TCGA	LTPTPS	DEG_SCF_FBW7_1	0.1389
p.A1227T	TCGA-AP-A051	UCEC	TCGA	LTPTPS	DEG_SCF_FBW7_1	0.1389
p.D1244N	TCGA-EE-A3AA	SKCM	TCGA	LTPTPS	DEG_SCF_FBW7_1	0.1944
p.H1225Y	SIDM00350	Head and Neck Carcinoma	GDSC	LTPTPS	DEG_SCF_FBW7_1	0.0833
p.H1225Y	SAT	upper_aerodigestive_tract	COSMIC	LTPTPS	DEG_SCF_FBW7_1	0.0833
p.P1236S	ACH-000904	Lung Cancer	CCLE	LTPTPS	DEG_SCF_FBW7_1	0.6752
p.P1236S	NCI-H1770	lung	COSMIC	LTPTPS	DEG_SCF_FBW7_1	0.6752
p.D1233N	TGW	autonomic_ganglia	COSMIC	LTPTPS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15085	Rho guanine nucleotide exchange factor 11	DEG_SCF_FBW7_1	1234:1239	LTPTPS	FBXW7	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons