DegronMD

Uniprot ID: O15085

Source protein: Rho guanine nucleotide exchange factor 11

Source gene: ARHGEF11

Class: DEG_SCF_TRCP1_1

Location: 220:225

E3 ligase: BTRC

DEGRON score: 0.8594

ASA_SCORE: 82.2833

COIL: 0.9167

CONS_SCORE: 0.3203

DSS_SCORE: 0.6773

HELIX: 0.0672

FCONS_SCORE: 0.9214

RIG_SCORE: 0.5848

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R216L	TCGA-49-AARQ	LUAD	TCGA	DSGLDS	DEG_SCF_TRCP1_1	0.6667
p.R216L	DO51189	LUAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.6667
p.L222V	TCGA-D9-A6EC	SKCM	TCGA	DSGLDS	DEG_SCF_TRCP1_1	0.6765
p.L222V	DO50291	SKCM	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.6765
p.G232V	TCGA-FF-8046	DLBC	TCGA	DSGLDS	DEG_SCF_TRCP1_1	0.5833
p.G232V	DO222303	DLBC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.5833
p.K225N	TCGA-GU-A766	BLCA	TCGA	DSGLDS	DEG_SCF_TRCP1_1	0.6918
p.K225N	DO51891	BLCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.6918
p.D227Y	DO6144	BRCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.2778
p.R229C	DO9010	COAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.2222
p.R229C	DO233903	GACA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.2222
p.R229C	DO228253	MALY	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.2222
p.Q221E	DO224801	COCA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.6744
p.E213K	DO49683	LIAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.5833
p.S225F	DO229052	LICA	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.7982
p.S234C	DO52193	LIHC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.0833
p.G235V	DO231708	LINC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.0556
p.G226V	DO37831	SKCM	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.3056
p.K223R	DO47849	STAD	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.7237
p.F230L	DO42568	UCEC	ICGC	DSGLDS	DEG_SCF_TRCP1_1	0.1944
p.E229K	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	DSGLDS	DEG_SCF_TRCP1_1	0.2222
p.E229K	ACH-000544	Esophageal Cancer	CCLE	DSGLDS	DEG_SCF_TRCP1_1	0.2222
p.E229K	OE21	oesophagus	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.2222
p.E210A	ACH-001450	Lymphoma	CCLE	DSGLDS	DEG_SCF_TRCP1_1	0.0556
p.L214V	UM-UC-3	urinary_tract	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.1667
p.R211Q	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.0833
p.D224H	OVTOKO	ovary	COSMIC	DSGLDS	DEG_SCF_TRCP1_1	0.6577

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SCF_TRCP1_1	474:479	DSGLDS	BTRC	0.9627	More...
O15085	Rho guanine nucleotide exchange factor 11	DEG_SCF_TRCP1_1	220:225	DSGLDS	BTRC	0.8594	More...
P25963	NF-kappa-B inhibitor alpha	DEG_SCF_TRCP1_1	31:36	DSGLDS	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGLDS

Degron related mutations and impact score

Drug responses associated with ARHGEF11 mutations

All proteins holding degron of DSGLDS