DegronMD

Uniprot ID: Q96KR1

Source protein: Zinc finger RNA-binding protein

Source gene: ZFR

Class: DEG_SPOP_SBC_1

Location: 431:435

E3 ligase: SPOP

DEGRON score: 0.9583

ASA_SCORE: 80.7

COIL: 0.8964

CONS_SCORE: 0.373

DSS_SCORE: 0.5009

HELIX: 0.0464

FCONS_SCORE: 0.837

RIG_SCORE: 0.6822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S440L	TCGA-A4-7583	KIRP	TCGA	ATSST	DEG_SPOP_SBC_1	0.1944
p.S440L	DO20870	KIRP	ICGC	ATSST	DEG_SPOP_SBC_1	0.1944
p.P421T	TCGA-AX-A2HC	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.0556
p.P421T	DO41572	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.0556
p.A439V	TCGA-BH-A0HF	BRCA	TCGA	ATSST	DEG_SPOP_SBC_1	0.2222
p.A439V	DO1749	BRCA	ICGC	ATSST	DEG_SPOP_SBC_1	0.2222
p.P421L	TCGA-DD-AADK	LIHC	TCGA	ATSST	DEG_SPOP_SBC_1	0.0556
p.P421L	DO52235	LIHC	ICGC	ATSST	DEG_SPOP_SBC_1	0.0556
p.A444L	DO223508	CLLE	ICGC	ATSST	DEG_SPOP_SBC_1	0.0833
p.P425Q	DO229008	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	0.1667
p.N426T	SIDM00741	Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.1944
p.N426T	ACH-000431	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.1944
p.N426T	NCI-H1694	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.1944
p.A436T	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.A436T	ACH-000925	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SPOP_SBC_1	742:746	ATSST	SPOP	0.8838	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	667:671	ATSST	SPOP	0.9758	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	450:454	ATSST	SPOP	0.9979	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	1850:1854	ATSST	SPOP	0.9984	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1948:1952	ATSST	SPOP	0.9534	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	545:549	ATSST	SPOP	0.9791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3201:3205	ATSST	SPOP	0.7972	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	508:512	ATSST	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6355:6359	ATSST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6643:6647	ATSST	SPOP	0.9478	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6733:6737	ATSST	SPOP	0.9478	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	16:20	ATSST	SPOP	0.8574	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	922:926	ATSST	SPOP	0.9792	More...
Q9C0G6	Dynein axonemal heavy chain 6	DEG_SPOP_SBC_1	116:120	ATSST	SPOP	0.9908	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4375:4379	ATSST	SPOP	0.8031	More...
Q9NP66	High mobility group protein 20A	DEG_SPOP_SBC_1	42:46	ATSST	SPOP	0.9289	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	2451:2455	ATSST	SPOP	0.9815	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	431:435	ATSST	SPOP	0.9583	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	727:731	ATSST	SPOP	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSST

Degron related mutations and impact score

Drug responses associated with ZFR mutations

All proteins holding degron of ATSST