DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3201:3205

E3 ligase: SPOP

DEGRON score: 0.7972

ASA_SCORE: 85.12

COIL: 0.9044

CONS_SCORE: 0.6517

DSS_SCORE: 0.6546

HELIX: 0.0212

FCONS_SCORE: 1.0001

RIG_SCORE: 0.6539

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3206S	TCGA-76-6286	GBM	TCGA	ATSST	DEG_SPOP_SBC_1	0.3056
p.T3206S	DO13552	GBM	ICGC	ATSST	DEG_SPOP_SBC_1	0.3056
p.T3199S	TCGA-A6-6649	COAD	TCGA	ATSST	DEG_SPOP_SBC_1	0.2778
p.T3199S	DO9186	COAD	ICGC	ATSST	DEG_SPOP_SBC_1	0.2778
p.A3201S	TCGA-B5-A0JY	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.7588
p.A3201S	DO43041	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.7588
p.S3192N	TCGA-BS-A0UA	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.0833
p.S3192N	DO42552	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.0833
p.T3214A	TCGA-DA-A1HY	SKCM	TCGA	ATSST	DEG_SPOP_SBC_1	0.0833
p.T3214A	DO37409	SKCM	ICGC	ATSST	DEG_SPOP_SBC_1	0.0833
p.T3202S	DO229030	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	0.6005
p.I3212M	DO229030	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	0.1389
p.T3191N	SIDM01119	Other Solid Cancers	GDSC	ATSST	DEG_SPOP_SBC_1	0.0556
p.T3191N	ACH-000775	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.0556
p.T3191N	NCI-H727	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.0556
p.S3192R	SIDM01119	Other Solid Cancers	GDSC	ATSST	DEG_SPOP_SBC_1	0.0833
p.S3192R	ACH-000775	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.0833
p.S3192R	NCI-H727	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.0833
p.S3203L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.7667
p.S3203L	NCI-H1648	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.7667
p.T3193I	SIDM00442	Thyroid Gland Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.1111
p.T3193I	ML-1	thyroid	COSMIC	ATSST	DEG_SPOP_SBC_1	0.1111
p.T3206A	SIDM00529	Breast Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.T3206A	SIDM00203	Ewing's Sarcoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.T3206A	SIDM00879	Breast Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.T3206A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.T3206A	SIDM00032	Bladder Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.T3206A	SIDM00068	Colorectal Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.T3206A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SPOP_SBC_1	742:746	ATSST	SPOP	0.8838	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	667:671	ATSST	SPOP	0.9758	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	450:454	ATSST	SPOP	0.9979	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	1850:1854	ATSST	SPOP	0.9984	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1948:1952	ATSST	SPOP	0.9534	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	545:549	ATSST	SPOP	0.9791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3201:3205	ATSST	SPOP	0.7972	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	508:512	ATSST	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6355:6359	ATSST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6643:6647	ATSST	SPOP	0.9478	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6733:6737	ATSST	SPOP	0.9478	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	16:20	ATSST	SPOP	0.8574	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	922:926	ATSST	SPOP	0.9792	More...
Q9C0G6	Dynein axonemal heavy chain 6	DEG_SPOP_SBC_1	116:120	ATSST	SPOP	0.9908	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4375:4379	ATSST	SPOP	0.8031	More...
Q9NP66	High mobility group protein 20A	DEG_SPOP_SBC_1	42:46	ATSST	SPOP	0.9289	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	2451:2455	ATSST	SPOP	0.9815	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	431:435	ATSST	SPOP	0.9583	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	727:731	ATSST	SPOP	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSST

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of ATSST