DegronMD - Q9C0G6(DNAH6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R3630Q	TCGA-AA-3510	COAD	TCGA	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation altering degron motif	0.7329
p.R3630Q	DO7783	COAD	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation altering degron motif	0.7329
p.K112N	TCGA-AN-A046	BRCA	TCGA	ATSST	DEG_SPOP_SBC_1	116:120	Mutation substituting flanking lysine	0.3333
p.K112N	DO1285	BRCA	ICGC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation substituting flanking lysine	0.3333
p.L3646I	TCGA-AN-A046	BRCA	TCGA	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.0833
p.L3646I	DO1285	BRCA	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.0833
p.L3646I	SIDM00193	Colorectal Carcinoma	GDSC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.0833
p.L3646I	ACH-000991	Colon/Colorectal Cancer	CCLE	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.0833
p.L3646I	SNU-81	large intestine	COSMIC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.0833
p.R106H	TCGA-AX-A2HC	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0556
p.R106H	DO52669	MALY	ICGC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0556
p.R106H	DO41572	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0556
p.P3621S	TCGA-AX-A2HC	UCEC	TCGA	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.1111
p.P3621S	DO41572	UCEC	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.1111
p.D127Y	TCGA-E6-A1LX	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.D127Y	DO41020	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.V3645I	TCGA-FI-A2D5	UCEC	TCGA	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.1111
p.V3645I	DO41331	UCEC	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.1111
p.K130E	TCGA-NH-A5IV	COAD	TCGA	ATSST	DEG_SPOP_SBC_1	116:120	Mutation substituting flanking lysine	0.1667
p.K130E	DO49095	COAD	ICGC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation substituting flanking lysine	0.1667
p.S119Y	DO20905	KIRP	ICGC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation altering degron motif	0.712
p.F115V	DO229024	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.3056
p.P3637L	DO220891	MELA	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation altering degron motif	0.6471
p.P3642S	DO220899	MELA	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.1944
p.P3642S	SIDM01105	Melanoma	GDSC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.1944
p.P3642S	ACH-000423	Skin Cancer	CCLE	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.1944
p.P3642S	SK-MEL-3	skin	COSMIC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.1944
p.V108I	DO222843	MELA	ICGC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1111
p.N3639K	DO49123	PACA	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation rewiring degron network	0.2778
p.E124V	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.2222
p.E124V	ACH-001363	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.2222
p.E124V	NCI-H2135	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.2222
p.S3634N	SIDM00554	Ovarian Carcinoma	GDSC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation altering degron motif	0.7069
p.S3634N	ACH-000524	Ovarian Cancer	CCLE	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation altering degron motif	0.7069
p.S3634N	KURAMOCHI	ovary	COSMIC	FRLFLSSMP	DEG_APCC_DBOX_1	3629:3637	Mutation altering degron motif	0.7069
p.F122V	ACH-001834	Bile Duct Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.2778

Kaplan plot for DNAH6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAH6

UniProt ID: Q9C0G6

Entrez ID: 1768

Protein name: Dynein axonemal heavy chain 6 (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAH6 in