DegronMD

Uniprot ID: Q9C0G6

Source protein: Dynein axonemal heavy chain 6

Source gene: DNAH6

Class: DEG_APCC_DBOX_1

Location: 3629:3637

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5613

ASA_SCORE: 19.5556

COIL: 0.3088

CONS_SCORE: 0.8023

DSS_SCORE: 0.2037

HELIX: 0.0118

FCONS_SCORE: 1.533

RIG_SCORE: 0.8092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3630Q	TCGA-AA-3510	COAD	TCGA	FRLFLSSMP	DEG_APCC_DBOX_1	0.7329
p.R3630Q	DO7783	COAD	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	0.7329
p.L3646I	TCGA-AN-A046	BRCA	TCGA	FRLFLSSMP	DEG_APCC_DBOX_1	0.0833
p.L3646I	DO1285	BRCA	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	0.0833
p.L3646I	SIDM00193	Colorectal Carcinoma	GDSC	FRLFLSSMP	DEG_APCC_DBOX_1	0.0833
p.L3646I	ACH-000991	Colon/Colorectal Cancer	CCLE	FRLFLSSMP	DEG_APCC_DBOX_1	0.0833
p.L3646I	SNU-81	large_intestine	COSMIC	FRLFLSSMP	DEG_APCC_DBOX_1	0.0833
p.P3621S	TCGA-AX-A2HC	UCEC	TCGA	FRLFLSSMP	DEG_APCC_DBOX_1	0.1111
p.P3621S	DO41572	UCEC	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	0.1111
p.V3645I	TCGA-FI-A2D5	UCEC	TCGA	FRLFLSSMP	DEG_APCC_DBOX_1	0.1111
p.V3645I	DO41331	UCEC	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	0.1111
p.P3637L	DO220891	MELA	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	0.6471
p.P3642S	DO220899	MELA	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	0.1944
p.P3642S	SIDM01105	Melanoma	GDSC	FRLFLSSMP	DEG_APCC_DBOX_1	0.1944
p.P3642S	ACH-000423	Skin Cancer	CCLE	FRLFLSSMP	DEG_APCC_DBOX_1	0.1944
p.P3642S	SK-MEL-3	skin	COSMIC	FRLFLSSMP	DEG_APCC_DBOX_1	0.1944
p.N3639K	DO49123	PACA	ICGC	FRLFLSSMP	DEG_APCC_DBOX_1	0.2778
p.S3634N	SIDM00554	Ovarian Carcinoma	GDSC	FRLFLSSMP	DEG_APCC_DBOX_1	0.7069
p.S3634N	ACH-000524	Ovarian Cancer	CCLE	FRLFLSSMP	DEG_APCC_DBOX_1	0.7069
p.S3634N	KURAMOCHI	ovary	COSMIC	FRLFLSSMP	DEG_APCC_DBOX_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0G6	Dynein axonemal heavy chain 6	DEG_APCC_DBOX_1	3629:3637	FRLFLSSMP	APC,CDC20,FZR1	0.5613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons