DegronMD

Uniprot ID: Q9C0G6

Source protein: Dynein axonemal heavy chain 6

Source gene: DNAH6

Class: DEG_SPOP_SBC_1

Location: 116:120

E3 ligase: SPOP

DEGRON score: 0.9908

ASA_SCORE: 76.36

COIL: 0.7312

CONS_SCORE: 0.2727

DSS_SCORE: 0.3489

HELIX: 0.2432

FCONS_SCORE: 1.106

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K112N	TCGA-AN-A046	BRCA	TCGA	ATSST	DEG_SPOP_SBC_1	0.3333
p.K112N	DO1285	BRCA	ICGC	ATSST	DEG_SPOP_SBC_1	0.3333
p.R106H	TCGA-AX-A2HC	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.0556
p.R106H	DO52669	MALY	ICGC	ATSST	DEG_SPOP_SBC_1	0.0556
p.R106H	DO41572	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.0556
p.D127Y	TCGA-E6-A1LX	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.1389
p.D127Y	DO41020	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.1389
p.K130E	TCGA-NH-A5IV	COAD	TCGA	ATSST	DEG_SPOP_SBC_1	0.1667
p.K130E	DO49095	COAD	ICGC	ATSST	DEG_SPOP_SBC_1	0.1667
p.S119Y	DO20905	KIRP	ICGC	ATSST	DEG_SPOP_SBC_1	0.712
p.F115V	DO229024	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	0.3056
p.V108I	DO222843	MELA	ICGC	ATSST	DEG_SPOP_SBC_1	0.1111
p.E124V	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.2222
p.E124V	ACH-001363	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.2222
p.E124V	NCI-H2135	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.2222
p.F122V	ACH-001834	Bile Duct Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SPOP_SBC_1	742:746	ATSST	SPOP	0.8838	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	667:671	ATSST	SPOP	0.9758	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	450:454	ATSST	SPOP	0.9979	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	1850:1854	ATSST	SPOP	0.9984	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1948:1952	ATSST	SPOP	0.9534	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	545:549	ATSST	SPOP	0.9791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3201:3205	ATSST	SPOP	0.7972	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	508:512	ATSST	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6355:6359	ATSST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6643:6647	ATSST	SPOP	0.9478	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6733:6737	ATSST	SPOP	0.9478	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	16:20	ATSST	SPOP	0.8574	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	922:926	ATSST	SPOP	0.9792	More...
Q9C0G6	Dynein axonemal heavy chain 6	DEG_SPOP_SBC_1	116:120	ATSST	SPOP	0.9908	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4375:4379	ATSST	SPOP	0.8031	More...
Q9NP66	High mobility group protein 20A	DEG_SPOP_SBC_1	42:46	ATSST	SPOP	0.9289	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	2451:2455	ATSST	SPOP	0.9815	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	431:435	ATSST	SPOP	0.9583	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	727:731	ATSST	SPOP	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSST

Degron related mutations and impact score

Drug responses associated with DNAH6 mutations

All proteins holding degron of ATSST