DegronMD

Uniprot ID: Q96KR1

Source protein: Zinc finger RNA-binding protein

Source gene: ZFR

Class: DEG_SCF_FBW7_1

Location: 526:533

E3 ligase: FBXW7

DEGRON score: 0.9631

ASA_SCORE: 94.625

COIL: 0.8854

CONS_SCORE: 0.292

DSS_SCORE: 0.4059

HELIX: 0.0281

FCONS_SCORE: 1.0555

RIG_SCORE: 0.7623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D543E	TCGA-AX-A06F	UCEC	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	0.0556
p.D543E	DO41752	UCEC	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.0556
p.E524K	TCGA-CL-5917	READ	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	0.2778
p.E524K	TCGA-E6-A1M0	UCEC	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	0.2778
p.E524K	DO36560	READ	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.2778
p.E524K	DO43682	UCEC	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.2778
p.P538S	TCGA-E6-A1LX	UCEC	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	0.1944
p.P538S	DO41020	UCEC	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.1944
p.V540G	TCGA-G2-AA3B	BLCA	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	0.1389
p.V540G	DO51882	BLCA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.1389
p.E539K	TCGA-KQ-A41R	BLCA	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	0.1667
p.E539K	DO223592	BLCA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.1667
p.I520T	DO228483	BRCA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.1667
p.I520T	DO229005	COCA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.1667
p.I520T	DO229047	LICA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.1667
p.I520T	DO230550	LUSC	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.1667
p.P530H	DO228948	LICA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	0.7694
p.D543N	SIDM00572	Gastric Carcinoma	GDSC	VKSTPVTS	DEG_SCF_FBW7_1	0.0556
p.D543N	ACH-000911	Gastric Cancer	CCLE	VKSTPVTS	DEG_SCF_FBW7_1	0.0556
p.D543N	NUGC-3	stomach	COSMIC	VKSTPVTS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KR1	Zinc finger RNA-binding protein	DEG_SCF_FBW7_1	526:533	VKSTPVTS	FBXW7	0.9631	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons