DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_SPOP_SBC_1

Location: 921:925

E3 ligase: SPOP

DEGRON score: 0.9219

ASA_SCORE: 69.82

COIL: 0.6954

CONS_SCORE: 0.3175

DSS_SCORE: 0.4862

HELIX: 0.2522

FCONS_SCORE: 0.852

RIG_SCORE: 0.7182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D920Y	TCGA-35-4122	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.3056
p.D920Y	DO23782	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.3056
p.D920H	TCGA-CN-A6V1	HNSC	TCGA	VATSS	DEG_SPOP_SBC_1	0.3056
p.D920H	DO52048	HNSC	ICGC	VATSS	DEG_SPOP_SBC_1	0.3056
p.R933W	DO222955	BTCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.1111
p.R933W	SIDM00395	Neuroblastoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.1111
p.R933W	ACH-000099	Neuroblastoma	CCLE	VATSS	DEG_SPOP_SBC_1	0.1111
p.R933W	SIMA	autonomic_ganglia	COSMIC	VATSS	DEG_SPOP_SBC_1	0.1111
p.V917F	DO228952	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	0.2222
p.S912F	DO220872	MELA	ICGC	VATSS	DEG_SPOP_SBC_1	0.5278
p.S912F	SIDM00545	Melanoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.5278
p.S912F	ACH-000987	Skin Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.5278
p.S912F	Mewo	skin	COSMIC	VATSS	DEG_SPOP_SBC_1	0.5278
p.V917A	SIDM00845	Burkitt's Lymphoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.2222
p.V917A	ACH-000992	Head and Neck Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.2222
p.V917A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.2222
p.A922G	SIDM00845	Burkitt's Lymphoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.6429
p.A922G	ACH-000992	Head and Neck Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.6429
p.A922G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.6429
p.K934N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	0.1944
p.K934N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.1944
p.V917I	SIDM00193	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.2222
p.V917I	ACH-000991	Colon/Colorectal Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.2222
p.V917I	SNU-81	large_intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	0.2222
p.D920G	SIDM01394	Kidney Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.3056
p.D920G	ACH-000907	Kidney Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	316:320	VATSS	SPOP	0.5471	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1761:1765	VATSS	SPOP	0.9537	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1557:1561	VATSS	SPOP	0.8877	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	971:975	VATSS	SPOP	0.9823	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	921:925	VATSS	SPOP	0.9219	More...
Q96CT7	Coiled-coil domain-containing protein 124	DEG_SPOP_SBC_1	89:93	VATSS	SPOP	0.9938	More...
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_SPOP_SBC_1	295:299	VATSS	SPOP	0.8406	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	1484:1488	VATSS	SPOP	0.8289	More...
O43638	Forkhead box protein S1	DEG_SPOP_SBC_1	208:212	VATSS	SPOP	0.8893	More...
O75363	Breast carcinoma-amplified sequence 1	DEG_SPOP_SBC_1	59:63	VATSS	SPOP	0.9947	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	461:465	VATSS	SPOP	0.9974	More...
Q6UX68	XK-related protein 5	DEG_SPOP_SBC_1	550:554	VATSS	SPOP	0.9819	More...
Q9BTE0	Alpha/beta-tubulin-N-acetyltransferase 9	DEG_SPOP_SBC_1	164:168	VATSS	SPOP	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VATSS

Degron related mutations and impact score

Drug responses associated with KMT2A mutations

All proteins holding degron of VATSS