DegronMD - Q6UX68(XKR5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q650E	SIDM00846	Cervical Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.0833
p.Q650E	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.0833
p.T670M	SIDM00334	Endometrial Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.2222
p.T670M	SIDM01101	Neuroblastoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.2222
p.T670M	SIDM00976	Melanoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.2222
p.A546T	SIDM00142	Endometrial Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	550:554	Mutation rewiring degron network	0.2222
p.A546T	SIDM00534	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	550:554	Mutation rewiring degron network	0.2222
p.A546T	COLO-684	endometrium	COSMIC	VATSS	DEG_SPOP_SBC_1	550:554	Mutation rewiring degron network	0.2222
p.A546T	HT-115	large intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	550:554	Mutation rewiring degron network	0.2222
p.T660M	SIDM00683	Prostate Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation altering degron motif	0.6312
p.L659V	SIDM00971	Breast Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation altering degron motif	0.5654
p.L659V	ZR-75-30	breast	COSMIC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation altering degron motif	0.5654
p.L651M	SIDM00324	Neuroblastoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.1111
p.L651M	TGW	autonomic ganglia	COSMIC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.1111
p.Q555E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	550:554	Mutation rewiring degron network	0.3056
p.Q555E	NCI-H1573	lung	COSMIC	VATSS	DEG_SPOP_SBC_1	550:554	Mutation rewiring degron network	0.3056
p.P649T	SIDM00217	Colorectal Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.0556
p.P649T	SNU-1040	large intestine	COSMIC	LTSTPKSE	DEG_SCF_FBW7_2	659:666	Mutation rewiring degron network	0.0556

Kaplan plot for XKR5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XKR5

UniProt ID: Q6UX68

Entrez ID: 389610

Protein name: XK-related protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XKR5 in