DegronMD

Uniprot ID: Q6UX68

Source protein: XK-related protein 5

Source gene: XKR5

Class: DEG_SCF_FBW7_2

Location: 659:666

E3 ligase: FBXW7

DEGRON score: 0.8912

ASA_SCORE: 72.7375

COIL: 0.7276

CONS_SCORE: 0.5066

DSS_SCORE: 0.4077

HELIX: 0.0308

FCONS_SCORE: 1.5683

RIG_SCORE: 0.6951

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q650E	SIDM00846	Cervical Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.0833
p.Q650E	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.0833
p.T670M	SIDM00334	Endometrial Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.2222
p.T670M	SIDM01101	Neuroblastoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.2222
p.T670M	SIDM00976	Melanoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.2222
p.T660M	SIDM00683	Prostate Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.6312
p.L659V	SIDM00971	Breast Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.5654
p.L659V	ZR-75-30	breast	COSMIC	LTSTPKSE	DEG_SCF_FBW7_2	0.5654
p.L651M	SIDM00324	Neuroblastoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.1111
p.L651M	TGW	autonomic_ganglia	COSMIC	LTSTPKSE	DEG_SCF_FBW7_2	0.1111
p.P649T	SIDM00217	Colorectal Carcinoma	GDSC	LTSTPKSE	DEG_SCF_FBW7_2	0.0556
p.P649T	SNU-1040	large_intestine	COSMIC	LTSTPKSE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UX68	XK-related protein 5	DEG_SCF_FBW7_2	659:666	LTSTPKSE	FBXW7	0.8912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons