DegronMD

Uniprot ID: Q6UX68

Source protein: XK-related protein 5

Source gene: XKR5

Class: DEG_SPOP_SBC_1

Location: 550:554

E3 ligase: SPOP

DEGRON score: 0.9819

ASA_SCORE: 59.54

COIL: 0.7804

CONS_SCORE: 0.3311

DSS_SCORE: 0.5708

HELIX: 0.0846

FCONS_SCORE: 0.8868

RIG_SCORE: 0.6908

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A546T	SIDM00142	Endometrial Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.2222
p.A546T	SIDM00534	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.2222
p.A546T	COLO-684	endometrium	COSMIC	VATSS	DEG_SPOP_SBC_1	0.2222
p.A546T	HT-115	large_intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	0.2222
p.Q555E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.3056
p.Q555E	NCI-H1573	lung	COSMIC	VATSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	316:320	VATSS	SPOP	0.5471	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1761:1765	VATSS	SPOP	0.9537	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1557:1561	VATSS	SPOP	0.8877	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	971:975	VATSS	SPOP	0.9823	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	921:925	VATSS	SPOP	0.9219	More...
Q96CT7	Coiled-coil domain-containing protein 124	DEG_SPOP_SBC_1	89:93	VATSS	SPOP	0.9938	More...
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_SPOP_SBC_1	295:299	VATSS	SPOP	0.8406	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	1484:1488	VATSS	SPOP	0.8289	More...
O43638	Forkhead box protein S1	DEG_SPOP_SBC_1	208:212	VATSS	SPOP	0.8893	More...
O75363	Breast carcinoma-amplified sequence 1	DEG_SPOP_SBC_1	59:63	VATSS	SPOP	0.9947	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	461:465	VATSS	SPOP	0.9974	More...
Q6UX68	XK-related protein 5	DEG_SPOP_SBC_1	550:554	VATSS	SPOP	0.9819	More...
Q9BTE0	Alpha/beta-tubulin-N-acetyltransferase 9	DEG_SPOP_SBC_1	164:168	VATSS	SPOP	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons