DegronMD

Uniprot ID: O43638

Source protein: Forkhead box protein S1

Source gene: FOXS1

Class: DEG_SCF_FBW7_1

Location: 234:239

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 68.1

COIL: 0.957

CONS_SCORE: 0.6043

DSS_SCORE: 0.4353

HELIX: 0.0148

FCONS_SCORE: 1.0492

RIG_SCORE: 0.7195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F224L	TCGA-AJ-A3EK	UCEC	TCGA	PTPVLS	DEG_SCF_FBW7_1	0.0556
p.F224L	TCGA-QF-A5YS	UCEC	TCGA	PTPVLS	DEG_SCF_FBW7_1	0.0556
p.F224L	DO41584	UCEC	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.0556
p.F224L	DO52426	UCEC	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.0556
p.G245E	TCGA-DU-6407	LGG	TCGA	PTPVLS	DEG_SCF_FBW7_1	0.1667
p.G245E	DO22295	LGG	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.1667
p.T235M	DO227692	COCA	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.7423
p.T235M	SIDM00151	Ovarian Carcinoma	GDSC	PTPVLS	DEG_SCF_FBW7_1	0.7423
p.T235M	ACH-000966	Ovarian Cancer	CCLE	PTPVLS	DEG_SCF_FBW7_1	0.7423
p.T235M	IGROV-1	ovary	COSMIC	PTPVLS	DEG_SCF_FBW7_1	0.7423
p.F230C	DO222762	COCA	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.2222
p.V237F	DO228562	LICA	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.5957
p.V237F	DO228807	LICA	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.5957
p.A233D	DO229015	LICA	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.3056
p.A233D	DO229037	LICA	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.3056
p.E226K	DO222395	MELA	ICGC	PTPVLS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43638	Forkhead box protein S1	DEG_SCF_FBW7_1	234:239	PTPVLS	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons