DegronMD

Uniprot ID: O94991

Source protein: SLIT and NTRK-like protein 5

Source gene: SLITRK5

Class: DEG_SCF_FBW7_1

Location: 296:302

E3 ligase: FBXW7

DEGRON score: 0.9906

ASA_SCORE: 54.7429

COIL: 0.8233

CONS_SCORE: 0.6563

DSS_SCORE: 0.4833

HELIX: 0.0744

FCONS_SCORE: 1.0494

RIG_SCORE: 0.7014

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E293K	TCGA-18-3409	LUSC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.25
p.E293K	TCGA-A6-5661	COAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.25
p.P310Q	TCGA-43-2576	LUSC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.1111
p.T308N	TCGA-44-3918	LUAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.1667
p.P296L	TCGA-69-7980	LUAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.6471
p.P296L	TCGA-AG-A002	READ	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.6471
p.R286S	TCGA-A5-A1OF	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.0556
p.T298M	TCGA-AX-A2HA	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.7423
p.T298M	TCGA-D5-6928	COAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.7423
p.P310L	TCGA-D1-A167	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.1111
p.P310L	SIDM01560	Rhabdomyosarcoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.1111
p.L306S	TCGA-EY-A214	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.2222
p.E293D	TCGA-N9-A4Q7	UCS	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.25
p.H307Y	TCGA-VS-A8EC	CESC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.H307Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.H307Y	ACH-000937	Leukemia	CCLE	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.H307Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.G286R	DO1110	BRCA	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.0556
p.L287F	DO6290	CESC	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.0833
p.L302V	DO8842	COAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6765
p.L302V	DO46657	PAAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6765
p.L302F	DO8546	COAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6981
p.L302F	DO229031	LICA	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6981
p.D309E	DO233178	GACA	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.1389
p.S301F	DO233762	GACA	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6871
p.L290P	DO18016	KIRC	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.1667
p.R291M	DO23629	LUAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.P299H	SIDM02016	Colorectal Carcinoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.7694
p.T308I	SIDM00453	Pancreatic Carcinoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.1667
p.T308I	ACH-000023	Pancreatic Cancer	CCLE	PQTPLST	DEG_SCF_FBW7_1	0.1667
p.T308I	PA-TU-8988T	pancreas	COSMIC	PQTPLST	DEG_SCF_FBW7_1	0.1667
p.T298K	SIDM01442	Glioma	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.7306
p.T298K	ACH-000807	Brain Cancer	CCLE	PQTPLST	DEG_SCF_FBW7_1	0.7306

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTPLST

Degron related mutations and impact score

Drug responses associated with SLITRK5 mutations

All proteins holding degron of PQTPLST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SCF_FBW7_1	296:302	PQTPLST	FBXW7	0.9906	More...