DegronMD

Uniprot ID: O94991

Source protein: SLIT and NTRK-like protein 5

Source gene: SLITRK5

Class: DEG_SCF_FBW7_1

Location: 296:302

E3 ligase: FBXW7

DEGRON score: 0.9906

ASA_SCORE: 54.7429

COIL: 0.8233

CONS_SCORE: 0.6563

DSS_SCORE: 0.4833

HELIX: 0.0744

FCONS_SCORE: 1.0494

RIG_SCORE: 0.7014

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P299H	SIDM02016	Colorectal Carcinoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.7694
p.T298M	TCGA-AX-A2HA	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.7423
p.T298M	TCGA-D5-6928	COAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.7423
p.T298K	SIDM01442	Glioma	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.7306
p.T298K	ACH-000807	Brain Cancer	CCLE	PQTPLST	DEG_SCF_FBW7_1	0.7306
p.L302F	DO8546	COAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6981
p.L302F	DO229031	LICA	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6981
p.S301F	DO233762	GACA	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6871
p.L302V	DO8842	COAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6765
p.L302V	DO46657	PAAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.6765
p.P296L	TCGA-69-7980	LUAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.6471
p.P296L	TCGA-AG-A002	READ	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.6471
p.E293K	TCGA-18-3409	LUSC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.25
p.E293K	TCGA-A6-5661	COAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.25
p.E293D	TCGA-N9-A4Q7	UCS	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.25
p.L306S	TCGA-EY-A214	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.2222
p.H307Y	TCGA-VS-A8EC	CESC	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.H307Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.H307Y	ACH-000937	Leukemia	CCLE	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.H307Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.R291M	DO23629	LUAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.1944
p.T308N	TCGA-44-3918	LUAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	0.1667
p.L290P	DO18016	KIRC	ICGC	PQTPLST	DEG_SCF_FBW7_1	0.1667
p.T308I	SIDM00453	Pancreatic Carcinoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	0.1667
p.T308I	ACH-000023	Pancreatic Cancer	CCLE	PQTPLST	DEG_SCF_FBW7_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SCF_FBW7_1	296:302	PQTPLST	FBXW7	0.9906	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons