DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3464:3468

E3 ligase: SPOP

DEGRON score: 0.5305

ASA_SCORE: 87.42

COIL: 0.8816

CONS_SCORE: 0.5236

DSS_SCORE: 0.5967

HELIX: 0.0142

FCONS_SCORE: 0.9593

RIG_SCORE: 0.7033

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3464T	TCGA-33-AAS8	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7031
p.P3464T	DO219123	LUSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7031
p.P3464H	TCGA-AX-A2HC	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7694
p.P3464H	DO41572	UCEC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7694
p.P3469L	TCGA-CR-7376	HNSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.3056
p.P3469L	DO15455	HNSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.3056
p.P3469L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PLSTT	DEG_SPOP_SBC_1	0.3056
p.L3478F	TCGA-E6-A1LX	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.0556
p.L3478F	DO41020	UCEC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.0556
p.A3475T	TCGA-EE-A29M	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1389
p.A3475T	DO37404	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.P3464L	TCGA-EE-A3J4	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7582
p.P3464L	DO48604	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7582
p.T3468M	TCGA-HU-8249	STAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7423
p.T3468M	DO47845	STAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7423
p.T3458A	DO223009	ESCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1667
p.S3472I	DO228948	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.2222
p.A3471V	DO228950	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.25
p.S3466I	DO229025	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7341
p.P3459L	DO222521	MELA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.V3470L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.2778
p.V3470L	ACH-000789	Lung Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.2778
p.V3470L	NCI-H810	lung	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.2778
p.A3475V	SIDM00113	Kidney Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.A3475V	ACH-001208	Kidney Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1389
p.A3475V	TK10	kidney	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.S3457N	SIDM00654	Small Cell Lung Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.S3473C	SIDM00892	Breast Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.S3473C	ACH-000818	Breast Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1944
p.S3473C	BT-483	breast	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P3459A	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P3459A	ACH-000694	Esophageal Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P3459A	TE-9	oesophagus	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.S3461L	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.25
p.S3461L	ACH-000694	Esophageal Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.25
p.S3461L	TE-9	oesophagus	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.25
p.P3469S	SIDM01608	Endometrial Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.3056
p.P3469S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.3056
p.P3469S	ACH-002287	Colon/Colorectal Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.3056
p.P3469S	NCI-H630	large_intestine	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.3056
p.G3456E	ACH-001982	Metastasis	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94910	Adhesion G protein-coupled receptor L1	DEG_SPOP_SBC_1	410:414	PLSTT	SPOP	0.9976	More...
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	299:303	PLSTT	SPOP	0.9511	More...
O95319	CUGBP Elav-like family member 2	DEG_SPOP_SBC_1	304:308	PLSTT	SPOP	0.7964	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2108:2112	PLSTT	SPOP	0.6286	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3464:3468	PLSTT	SPOP	0.5305	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	904:908	PLSTT	SPOP	0.931	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	443:447	PLSTT	SPOP	0.9874	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1064:1068	PLSTT	SPOP	0.9334	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2228:2232	PLSTT	SPOP	0.9645	More...
O60347	TBC1 domain family member 12	DEG_SPOP_SBC_1	391:395	PLSTT	SPOP	0.9367	More...
Q9P1G2	Putative uncharacterized protein encoded by RBM12B-AS1	DEG_SPOP_SBC_1	24:28	PLSTT	SPOP	0.9186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PLSTT