DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2108:2112

E3 ligase: SPOP

DEGRON score: 0.6286

ASA_SCORE: 88.98

COIL: 0.9166

CONS_SCORE: 0.5236

DSS_SCORE: 0.5535

HELIX: 0.0096

FCONS_SCORE: 0.8728

RIG_SCORE: 0.6843

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2118G	TCGA-20-1686	OV	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1667
p.E2118G	DO31380	OV	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1667
p.T2112M	TCGA-4Z-AA7S	BLCA	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7423
p.T2112M	TCGA-HT-A74H	LGG	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7423
p.T2112M	DO218982	BLCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7423
p.T2112M	DO219815	LGG	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7423
p.T2112M	NCI-H1836	lung	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.7423
p.G2100E	TCGA-D3-A8GM	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1111
p.G2100E	DO50288	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1111
p.S2101N	TCGA-D6-6516	HNSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1389
p.S2101N	DO15623	HNSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.L2122F	TCGA-D9-A6EA	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.0556
p.L2122F	DO50290	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.0556
p.S2110I	TCGA-EE-A3JD	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7341
p.S2110I	DO50299	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7341
p.S2110R	TCGA-EE-A3JD	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7427
p.S2110R	TCGA-L9-A743	LUAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7427
p.S2110R	DO49874	LUAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7427
p.S2110R	DO50299	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7427
p.L2103V	TCGA-FD-A5C1	BLCA	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1944
p.L2103V	DO44043	BLCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.S2106R	TCGA-HU-A4GH	STAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.2778
p.S2106R	DO47743	STAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.2778
p.L2109V	DO229376	BTCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.5654
p.P2108S	DO234237	ESAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.6752
p.P2108H	DO233624	GACA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7694
p.P2117S	DO228960	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.A2119S	DO229009	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.T2105A	DO51576	LUSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.25
p.E2118V	DO230530	LUSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1667
p.P2102L	DO220907	MELA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1667
p.P2117L	SIDM00321	Ovarian Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM00315	Glioblastoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM00296	Small Cell Lung Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM00360	Other Solid Cancers	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM00380	Acute Myeloid Leukemia	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM00877	Breast Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM01335	Kidney Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SIDM01526	Mesothelioma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	TYK-nu	ovary	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	QGP-1	pancreas	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	YKG-1	central_nervous_system	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	TE-15	oesophagus	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	HCC1599	breast	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	KYSE-450	oesophagus	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	LU-134-A	lung	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P2117L	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94910	Adhesion G protein-coupled receptor L1	DEG_SPOP_SBC_1	410:414	PLSTT	SPOP	0.9976	More...
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	299:303	PLSTT	SPOP	0.9511	More...
O95319	CUGBP Elav-like family member 2	DEG_SPOP_SBC_1	304:308	PLSTT	SPOP	0.7964	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2108:2112	PLSTT	SPOP	0.6286	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3464:3468	PLSTT	SPOP	0.5305	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	904:908	PLSTT	SPOP	0.931	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	443:447	PLSTT	SPOP	0.9874	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1064:1068	PLSTT	SPOP	0.9334	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2228:2232	PLSTT	SPOP	0.9645	More...
O60347	TBC1 domain family member 12	DEG_SPOP_SBC_1	391:395	PLSTT	SPOP	0.9367	More...
Q9P1G2	Putative uncharacterized protein encoded by RBM12B-AS1	DEG_SPOP_SBC_1	24:28	PLSTT	SPOP	0.9186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PLSTT