DegronMD - O60347(TBC1D12)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K385N	TCGA-AX-A2HD	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	391:395	Mutation substituting flanking lysine	0.2778
p.K385N	DO232761	PBCA	ICGC	PLSTT	DEG_SPOP_SBC_1	391:395	Mutation substituting flanking lysine	0.2778
p.K385N	DO42608	UCEC	ICGC	PLSTT	DEG_SPOP_SBC_1	391:395	Mutation substituting flanking lysine	0.2778
p.R384H	DO227979	COCA	ICGC	PLSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.R384H	DO228037	EOPC	ICGC	PLSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons