DegronMD

Uniprot ID: O60347

Source protein: TBC1 domain family member 12

Source gene: TBC1D12

Class: DEG_SPOP_SBC_1

Location: 391:395

E3 ligase: SPOP

DEGRON score: 0.9367

ASA_SCORE: 77.8

COIL: 0.7018

CONS_SCORE: 0.3339

DSS_SCORE: 0.507

HELIX: 0.2202

FCONS_SCORE: 1.0363

RIG_SCORE: 0.751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K385N	TCGA-AX-A2HD	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.2778
p.K385N	DO232761	PBCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.2778
p.K385N	DO42608	UCEC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.2778
p.R384H	DO227979	COCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.R384H	DO228037	EOPC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94910	Adhesion G protein-coupled receptor L1	DEG_SPOP_SBC_1	410:414	PLSTT	SPOP	0.9976	More...
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	299:303	PLSTT	SPOP	0.9511	More...
O95319	CUGBP Elav-like family member 2	DEG_SPOP_SBC_1	304:308	PLSTT	SPOP	0.7964	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2108:2112	PLSTT	SPOP	0.6286	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3464:3468	PLSTT	SPOP	0.5305	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	904:908	PLSTT	SPOP	0.931	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	443:447	PLSTT	SPOP	0.9874	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1064:1068	PLSTT	SPOP	0.9334	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2228:2232	PLSTT	SPOP	0.9645	More...
O60347	TBC1 domain family member 12	DEG_SPOP_SBC_1	391:395	PLSTT	SPOP	0.9367	More...
Q9P1G2	Putative uncharacterized protein encoded by RBM12B-AS1	DEG_SPOP_SBC_1	24:28	PLSTT	SPOP	0.9186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons