DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PLSTT
Uniprot ID:
Q9ULH7
Source protein:
Myocardin-related transcription factor B
Source gene:
MRTFB
Class:
DEG_SPOP_SBC_1
Location:
1064:1068
E3 ligase:
SPOP
DEGRON score:
0.9334
ASA_SCORE:
76.1
COIL:
0.9028
CONS_SCORE:
0.407
DSS_SCORE:
0.4552
HELIX:
0.0274
FCONS_SCORE:
0.9619
RIG_SCORE:
0.6816
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MRTFB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94910
Adhesion G protein-coupled receptor L1
DEG_SPOP_SBC_1
410:414
PLSTT
SPOP
0.9976
More...
O94991
SLIT and NTRK-like protein 5
DEG_SPOP_SBC_1
299:303
PLSTT
SPOP
0.9511
More...
O95319
CUGBP Elav-like family member 2
DEG_SPOP_SBC_1
304:308
PLSTT
SPOP
0.7964
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2108:2112
PLSTT
SPOP
0.6286
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3464:3468
PLSTT
SPOP
0.5305
More...
Q969V6
Myocardin-related transcription factor A
DEG_SPOP_SBC_1
904:908
PLSTT
SPOP
0.931
More...
Q9NZP6
Nuclear pore-associated protein 1
DEG_SPOP_SBC_1
443:447
PLSTT
SPOP
0.9874
More...
Q9ULH7
Myocardin-related transcription factor B
DEG_SPOP_SBC_1
1064:1068
PLSTT
SPOP
0.9334
More...
Q9Y3S1
Serine/threonine-protein kinase WNK2
DEG_SPOP_SBC_1
2228:2232
PLSTT
SPOP
0.9645
More...
O60347
TBC1 domain family member 12
DEG_SPOP_SBC_1
391:395
PLSTT
SPOP
0.9367
More...
Q9P1G2
Putative uncharacterized protein encoded by RBM12B-AS1
DEG_SPOP_SBC_1
24:28
PLSTT
SPOP
0.9186
More...