DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_SPOP_SBC_1

Location: 2228:2232

E3 ligase: SPOP

DEGRON score: 0.9645

ASA_SCORE: 70.84

COIL: 0.8542

CONS_SCORE: 0.318

DSS_SCORE: 0.5569

HELIX: 0.0722

FCONS_SCORE: 0.9649

RIG_SCORE: 0.6487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2229M	TCGA-37-3789	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.5999
p.A2238T	TCGA-A5-A1OF	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1667
p.P2239L	TCGA-B1-A47M	KIRP	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1389
p.P2239L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.P2239L	ACH-000938	Leukemia	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1389
p.P2239L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.V2233I	TCGA-D9-A6EC	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.3056
p.P2235L	TCGA-EE-A29C	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.25
p.P2235L	TCGA-L5-A8NM	ESCA	TCGA	PLSTT	DEG_SPOP_SBC_1	0.25
p.A2225T	TCGA-EO-A3B0	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.25
p.R2221C	TCGA-EY-A549	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1389
p.R2221C	SIDM00075	Non-Cancerous	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.R2221C	SIDM00566	Oral Cavity Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.R2221C	SIDM00604	Oral Cavity Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.R2221C	SIDM01753	Gastric Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.A2225V	TCGA-XK-AAIW	PRAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94910	Adhesion G protein-coupled receptor L1	DEG_SPOP_SBC_1	410:414	PLSTT	SPOP	0.9976	More...
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	299:303	PLSTT	SPOP	0.9511	More...
O95319	CUGBP Elav-like family member 2	DEG_SPOP_SBC_1	304:308	PLSTT	SPOP	0.7964	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2108:2112	PLSTT	SPOP	0.6286	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3464:3468	PLSTT	SPOP	0.5305	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	904:908	PLSTT	SPOP	0.931	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	443:447	PLSTT	SPOP	0.9874	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1064:1068	PLSTT	SPOP	0.9334	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2228:2232	PLSTT	SPOP	0.9645	More...
O60347	TBC1 domain family member 12	DEG_SPOP_SBC_1	391:395	PLSTT	SPOP	0.9367	More...
Q9P1G2	Putative uncharacterized protein encoded by RBM12B-AS1	DEG_SPOP_SBC_1	24:28	PLSTT	SPOP	0.9186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons