DegronMD

Uniprot ID: O95319

Source protein: CUGBP Elav-like family member 2

Source gene: CELF2

Class: DEG_SPOP_SBC_1

Location: 304:308

E3 ligase: SPOP

DEGRON score: 0.7964

ASA_SCORE: 49.98

COIL: 0.7674

CONS_SCORE: 0.4755

DSS_SCORE: 0.4519

HELIX: 0.1566

FCONS_SCORE: 1.0163

RIG_SCORE: 0.6927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S306I	TCGA-D5-6540	COAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7341
p.S306I	DO9708	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7341
p.A318T	TCGA-EJ-5522	PRAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.0556
p.S302P	DO48454	BLCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.2778
p.E316Q	DO834	BLCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1111
p.L315H	DO1436	BRCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.G315R	DO1269	BRCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.A309S	DO229029	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.3056
p.A314T	DO50968	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1667
p.A314T	SNU-1040	large_intestine	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1667
p.A306E	DO45456	LUSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7701
p.M308V	DO42985	UCEC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7208
p.N308S	SIDM00420	Bladder Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.7069
p.N308S	SIDM00006	Other Solid Cancers	GDSC	PLSTT	DEG_SPOP_SBC_1	0.7069
p.A309T	SIDM00217	Colorectal Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.3056
p.A309T	SNU-1040	large_intestine	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.3056
p.A306P	ACH-000395	Lung Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.7503
p.A306P	ACH-000667	Lung Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.7503
p.A306P	ACH-000930	Breast Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.7503
p.G315E	ACH-000983	Leukemia	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1389
p.G315E	ACH-002283	Neuroblastoma	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1389
p.G315E	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.G315E	NB5	autonomic_ganglia	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.A302T	SNU-1040	large_intestine	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94910	Adhesion G protein-coupled receptor L1	DEG_SPOP_SBC_1	410:414	PLSTT	SPOP	0.9976	More...
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	299:303	PLSTT	SPOP	0.9511	More...
O95319	CUGBP Elav-like family member 2	DEG_SPOP_SBC_1	304:308	PLSTT	SPOP	0.7964	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2108:2112	PLSTT	SPOP	0.6286	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3464:3468	PLSTT	SPOP	0.5305	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	904:908	PLSTT	SPOP	0.931	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	443:447	PLSTT	SPOP	0.9874	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1064:1068	PLSTT	SPOP	0.9334	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2228:2232	PLSTT	SPOP	0.9645	More...
O60347	TBC1 domain family member 12	DEG_SPOP_SBC_1	391:395	PLSTT	SPOP	0.9367	More...
Q9P1G2	Putative uncharacterized protein encoded by RBM12B-AS1	DEG_SPOP_SBC_1	24:28	PLSTT	SPOP	0.9186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons