DegronMD - Q9UKV3(ACIN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G37E	TCGA-55-8301	LUAD	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation altering degron motif	0.6087
p.G37E	DO24682	LUAD	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation altering degron motif	0.6087
p.P43Q	TCGA-55-8615	LUAD	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.3056
p.P43Q	DO24665	LUAD	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.3056
p.S895C	TCGA-BP-4988	KIRC	TCGA	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation blocking phosphorylation signal	0.7222
p.A48S	TCGA-BR-7851	STAD	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.1667
p.A48S	DO38711	STAD	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.1667
p.E899Q	TCGA-CF-A27C	BLCA	TCGA	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation rewiring degron network	0.1667
p.S578C	TCGA-DK-A3WW	BLCA	TCGA	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.7541
p.S578C	DO481	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.7541
p.L32I	TCGA-EO-A22X	UCEC	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.25
p.L32I	DO43907	UCEC	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.25
p.R40L	TCGA-GI-A2C8	BRCA	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation altering degron motif	0.7316
p.R40L	DO5992	BRCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation altering degron motif	0.7316
p.S587C	TCGA-IR-A3LL	CESC	TCGA	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0833
p.S587C	DO44362	CESC	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0833
p.R568I	DO51889	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.G581R	DO51889	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.25
p.M32V	DO225346	BRCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.25
p.S569I	DO222404	BTCA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1944
p.H31Y	DO222606	BTCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.2222
p.H31Y	SIDM01608	Endometrial Carcinoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.2222
p.H31Y	ACH-000990	Endometrial/Uterine Cancer	CCLE	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.2222
p.R583C	DO9314	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.6389
p.K564E	DO9114	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.R572Q	DO10582	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2778
p.R582C	DO8447	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2222
p.R582C	DO51761	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2222
p.R582C	DO41235	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2222
p.Y25C	DO227987	COCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.0556
p.P44L	DO227996	COCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.2778
p.S584T	DO233260	GACA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.6111
p.R582H	DO233766	GACA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2222
p.R583H	DO22237	LGG	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.6389
p.H566Q	DO228946	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.H566Q	DO228971	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.S588T	DO228998	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.5
p.R38S	DO229026	LICA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation altering degron motif	0.6316
p.S567R	DO229034	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.L564P	DO45161	LIRI	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.S569R	DO26240	LUAD	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1944
p.P575S	DO218861	SKCA	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.6752
p.R565H	DO51795	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0833
p.R577Q	DO48174	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.7329
p.P39S	DO42033	UCEC	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation altering degron motif	0.6752
p.H566Y	DO41847	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.P33H	DO42608	UCEC	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.2778
p.P31S	DO43755	UCEC	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.2222
p.H568Y	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.H568Y	ACH-000789	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.H568Y	NCI-H810	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1667
p.G28R	SIDM01197	Colorectal Carcinoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.1389
p.G28R	ACH-000722	Colon/Colorectal Cancer	CCLE	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.1389
p.G28R	SNU-C1	large intestine	COSMIC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.1389
p.A48V	SIDM00789	Colorectal Carcinoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.1667
p.A48V	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.1667
p.R580W	SIDM00197	Ewing's Sarcoma	GDSC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2778
p.R896H	SIDM00487	Colorectal Carcinoma	GDSC	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation rewiring degron network	0.25
p.R896H	ACH-000963	Colon/Colorectal Cancer	CCLE	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation rewiring degron network	0.25
p.R896H	CCK-81	large intestine	COSMIC	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation rewiring degron network	0.25
p.E901K	SIDM00290	Gastric Carcinoma	GDSC	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation rewiring degron network	0.1111
p.E901K	ACH-000847	Gastric Cancer	CCLE	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation rewiring degron network	0.1111
p.E901K	HGC-27	stomach	COSMIC	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation rewiring degron network	0.1111
p.S583L	SIDM00341	Squamous Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.6389
p.S583L	ACH-000176	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.6389
p.S583L	LOU-NH91	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.6389
p.E47K	SIDM00150	Colorectal Carcinoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.1944
p.R572W	LIM1215	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2778
p.R571W	LIM1215	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation substituting flanking lysine	0.3611
p.R43Q	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	FEGRWRKL	DEG_MDM2_SWIB_1	35:42	Mutation rewiring degron network	0.3056
p.R883H	CCK-81	large intestine	COSMIC	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation rewiring degron network	0.1944
p.S579P	CPC-N	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.3056
p.E888K	HGC-27	stomach	COSMIC	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation altering degron motif	0.7022
p.R584C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.6111
p.P893L	SK-UT-1	soft tissue	COSMIC	VDLHAD	LIG_APCC_ABBA_1	888:893	Mutation altering degron motif	0.7582
p.D582N	MKN7	stomach	COSMIC	ADSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACIN1

UniProt ID: Q9UKV3

Entrez ID: 22985

Protein name: Apoptotic chromatin condensation inducer in the nucleus (Acinus)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACIN1 in