DegronMD

Uniprot ID: Q9UKV3

Source protein: Apoptotic chromatin condensation inducer in the nucleus

Source gene: ACIN1

Class: LIG_APCC_ABBA_1

Location: 888:893

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9433

ASA_SCORE: 92.5167

COIL: 0.6857

CONS_SCORE: 0.3724

DSS_SCORE: 0.5278

HELIX: 0.2067

FCONS_SCORE: 0.9959

RIG_SCORE: 0.772

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S895C	TCGA-BP-4988	KIRC	TCGA	VDLHAD	LIG_APCC_ABBA_1	0.7222
p.E899Q	TCGA-CF-A27C	BLCA	TCGA	VDLHAD	LIG_APCC_ABBA_1	0.1667
p.R896H	SIDM00487	Colorectal Carcinoma	GDSC	VDLHAD	LIG_APCC_ABBA_1	0.25
p.R896H	ACH-000963	Colon/Colorectal Cancer	CCLE	VDLHAD	LIG_APCC_ABBA_1	0.25
p.R896H	CCK-81	large_intestine	COSMIC	VDLHAD	LIG_APCC_ABBA_1	0.25
p.E901K	SIDM00290	Gastric Carcinoma	GDSC	VDLHAD	LIG_APCC_ABBA_1	0.1111
p.E901K	ACH-000847	Gastric Cancer	CCLE	VDLHAD	LIG_APCC_ABBA_1	0.1111
p.E901K	HGC-27	stomach	COSMIC	VDLHAD	LIG_APCC_ABBA_1	0.1111
p.R883H	CCK-81	large_intestine	COSMIC	VDLHAD	LIG_APCC_ABBA_1	0.1944
p.E888K	HGC-27	stomach	COSMIC	VDLHAD	LIG_APCC_ABBA_1	0.7022
p.P893L	SK-UT-1	soft_tissue	COSMIC	VDLHAD	LIG_APCC_ABBA_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus	LIG_APCC_ABBA_1	888:893	VDLHAD	APC,CDC20,FZR1	0.9433	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons