DegronMD

Uniprot ID: Q9UKV3

Source protein: Apoptotic chromatin condensation inducer in the nucleus

Source gene: ACIN1

Class: DEG_SPOP_SBC_1

Location: 574:578

E3 ligase: SPOP

DEGRON score: 0.9639

ASA_SCORE: 90.3

COIL: 0.9324

CONS_SCORE: 0.3461

DSS_SCORE: 0.69

HELIX: 0.0632

FCONS_SCORE: 1.0644

RIG_SCORE: 0.5027

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S578C	TCGA-DK-A3WW	BLCA	TCGA	ADSSS	DEG_SPOP_SBC_1	0.7541
p.S578C	DO481	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.7541
p.S587C	TCGA-IR-A3LL	CESC	TCGA	ADSSS	DEG_SPOP_SBC_1	0.0833
p.S587C	DO44362	CESC	ICGC	ADSSS	DEG_SPOP_SBC_1	0.0833
p.R568I	DO51889	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1667
p.G581R	DO51889	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.25
p.S569I	DO222404	BTCA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1944
p.R583C	DO9314	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.6389
p.K564E	DO9114	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.0556
p.R572Q	DO10582	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.2778
p.R582C	DO8447	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.2222
p.R582C	DO51761	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.2222
p.R582C	DO41235	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	0.2222
p.S584T	DO233260	GACA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.6111
p.R582H	DO233766	GACA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.2222
p.R583H	DO22237	LGG	ICGC	ADSSS	DEG_SPOP_SBC_1	0.6389
p.H566Q	DO228946	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1111
p.H566Q	DO228971	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1111
p.S588T	DO228998	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.5
p.S567R	DO229034	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1389
p.L564P	DO45161	LIRI	ICGC	ADSSS	DEG_SPOP_SBC_1	0.0556
p.S569R	DO26240	LUAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1944
p.P575S	DO218861	SKCA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.6752
p.R565H	DO51795	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.0833
p.R577Q	DO48174	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	0.7329
p.H566Y	DO41847	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1111
p.H568Y	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.1667
p.H568Y	ACH-000789	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	0.1667
p.H568Y	NCI-H810	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.1667
p.R580W	SIDM00197	Ewing's Sarcoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.2778
p.S583L	SIDM00341	Squamous Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.6389
p.S583L	ACH-000176	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	0.6389
p.S583L	LOU-NH91	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.6389
p.R572W	LIM1215	large_intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.2778
p.R571W	LIM1215	large_intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.3611
p.S579P	CPC-N	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.3056
p.R584C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.6111
p.D582N	MKN7	stomach	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0MZ66	Shootin-1	DEG_SPOP_SBC_1	490:494	ADSSS	SPOP	0.992	More...
O14654	Insulin receptor substrate 4	DEG_SPOP_SBC_1	915:919	ADSSS	SPOP	0.9969	More...
O43187	Interleukin-1 receptor-associated kinase-like 2	DEG_SPOP_SBC_1	573:577	ADSSS	SPOP	0.6187	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1171:1175	ADSSS	SPOP	0.8432	More...
O95248	Myotubularin-related protein 5	DEG_SPOP_SBC_1	1235:1239	ADSSS	SPOP	0.5133	More...
P40197	Platelet glycoprotein V	DEG_SPOP_SBC_1	484:488	ADSSS	SPOP	0.6617	More...
P45973	Chromobox protein homolog 5	DEG_SPOP_SBC_1	9:13	ADSSS	SPOP	0.9016	More...
P98153	Integral membrane protein DGCR2/IDD	DEG_SPOP_SBC_1	511:515	ADSSS	SPOP	0.9946	More...
Q03468	DNA excision repair protein ERCC-6	DEG_SPOP_SBC_1	1377:1381	ADSSS	SPOP	0.9914	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	196:200	ADSSS	SPOP	0.9906	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	151:155	ADSSS	SPOP	0.9969	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	421:425	ADSSS	SPOP	0.9888	More...
Q6ZUT1	Uncharacterized protein NKAPD1	DEG_SPOP_SBC_1	181:185	ADSSS	SPOP	0.9937	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1077:1081	ADSSS	SPOP	0.9779	More...
Q86W24	NACHT, LRR and PYD domains-containing protein 14	DEG_SPOP_SBC_1	2:6	ADSSS	SPOP	0.8095	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	127:131	ADSSS	SPOP	0.8228	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19877:19881	ADSSS	SPOP	0.7426	More...
Q92834	X-linked retinitis pigmentosa GTPase regulator	DEG_SPOP_SBC_1	928:932	ADSSS	SPOP	0.9559	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	110:114	ADSSS	SPOP	0.9951	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	183:187	ADSSS	SPOP	0.9951	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	600:604	ADSSS	SPOP	0.9818	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	1055:1059	ADSSS	SPOP	0.9769	More...
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus	DEG_SPOP_SBC_1	574:578	ADSSS	SPOP	0.9639	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	82:86	ADSSS	SPOP	0.9679	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	929:933	ADSSS	SPOP	0.6557	More...
O15069	NAC-alpha domain-containing protein 1	DEG_SPOP_SBC_1	282:286	ADSSS	SPOP	0.9969	More...
Q66K14	TBC1 domain family member 9B	DEG_SPOP_SBC_1	355:359	ADSSS	SPOP	0.7361	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	494:498	ADSSS	SPOP	0.9841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADSSS

Degron related mutations and impact score

Drug responses associated with ACIN1 mutations

All proteins holding degron of ADSSS