DegronMD - O14654(IRS4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1005K	TCGA-05-4397	LUAD	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.2222
p.T1005K	DO25320	LUAD	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.2222
p.M924L	TCGA-22-4596	LUSC	TCGA	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1944
p.M924L	DO27739	LUSC	ICGC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1944
p.M924L	SKN	soft tissue	COSMIC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1944
p.R929I	TCGA-AA-3977	COAD	TCGA	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.0556
p.R929I	DO8730	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.0556
p.P719S	TCGA-AJ-A3EK	UCEC	TCGA	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.1667
p.P719S	DO41584	UCEC	ICGC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.1667
p.S917I	TCGA-AR-A0TP	BRCA	TCGA	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation altering degron motif	0.7341
p.S917I	DO1340	BRCA	ICGC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation altering degron motif	0.7341
p.P722H	TCGA-B5-A3FA	UCEC	TCGA	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.0833
p.P722H	DO52402	UCEC	ICGC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.0833
p.L1000I	TCGA-CM-6171	COAD	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation altering degron motif	0.6063
p.L1000I	DO8151	COAD	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation altering degron motif	0.6063
p.L1000F	TCGA-D3-A5GU	SKCM	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation altering degron motif	0.6981
p.L1000F	DO47584	SKCM	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation altering degron motif	0.6981
p.L997F	TCGA-DD-A1EE	LIHC	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation altering degron motif	0.6981
p.L997F	DO22857	LIHC	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation altering degron motif	0.6981
p.V701M	TCGA-FI-A2D0	UCEC	TCGA	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.1667
p.V701M	DO43891	UCEC	ICGC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.1667
p.A993G	TCGA-L9-A8F4	LUAD	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation altering degron motif	0.6429
p.A993G	DO49876	LUAD	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation altering degron motif	0.6429
p.R984C	TCGA-O2-A52Q	LUSC	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.0833
p.R984C	DO219219	LUSC	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.0833
p.D698N	TCGA-YC-A8S6	BLCA	TCGA	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.0833
p.D698N	DO49806	BLCA	ICGC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.0833
p.Y700F	DO231993	LICA	ICGC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation blocking phosphorylation signal	0.5833
p.D916E	DO229038	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation altering degron motif	0.5647
p.P908T	DO229009	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1389
p.D697H	DO23296	LINC	ICGC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.0556
p.D698H	DO224563	LUSC	ICGC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation rewiring degron network	0.0833
p.D925G	SIDM02014	Esophageal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1667
p.N986S	SIDM00282	Colorectal Carcinoma	GDSC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.1389
p.N986S	ACH-000998	Colon/Colorectal Cancer	CCLE	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.1389
p.N986S	CW-2	large intestine	COSMIC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.1389
p.H910D	SIDM00054	Pancreatic Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1944
p.H910D	ACH-002185	Pancreatic Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1944
p.H910D	PL18	pancreas	COSMIC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1944
p.A708V	SIDM00665	Gastric Carcinoma	GDSC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation altering degron motif	0.5825
p.A708V	ACH-000616	Gastric Cancer	CCLE	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation altering degron motif	0.5825
p.A708V	Hs746T	stomach	COSMIC	VATPLVS	DEG_SCF_FBW7_1	707:713	Mutation altering degron motif	0.5825
p.D991G	SIDM00863	Burkitt's Lymphoma	GDSC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.2778
p.D991G	EB2	haematopoietic and lymphoid tissue	COSMIC	ARWPLPPLP	DEG_APCC_DBOX_1	993:1001	Mutation rewiring degron network	0.2778
p.M924K	SKN	soft tissue	COSMIC	ADSSS	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1944

Kaplan plot for IRS4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRS4

UniProt ID: O14654

Entrez ID: 8471

Protein name: Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRS4 in