DegronMD

Uniprot ID: O14654

Source protein: Insulin receptor substrate 4

Source gene: IRS4

Class: DEG_APCC_DBOX_1

Location: 993:1001

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9871

ASA_SCORE: 79.4

COIL: 0.9186

CONS_SCORE: 0.3195

DSS_SCORE: 0.3413

HELIX: 0.0391

FCONS_SCORE: 0.8973

RIG_SCORE: 0.7262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1005K	TCGA-05-4397	LUAD	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	0.2222
p.T1005K	DO25320	LUAD	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	0.2222
p.L1000I	TCGA-CM-6171	COAD	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	0.6063
p.L1000I	DO8151	COAD	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	0.6063
p.L1000F	TCGA-D3-A5GU	SKCM	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	0.6981
p.L1000F	DO47584	SKCM	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	0.6981
p.L997F	TCGA-DD-A1EE	LIHC	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	0.6981
p.L997F	DO22857	LIHC	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	0.6981
p.A993G	TCGA-L9-A8F4	LUAD	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	0.6429
p.A993G	DO49876	LUAD	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	0.6429
p.R984C	TCGA-O2-A52Q	LUSC	TCGA	ARWPLPPLP	DEG_APCC_DBOX_1	0.0833
p.R984C	DO219219	LUSC	ICGC	ARWPLPPLP	DEG_APCC_DBOX_1	0.0833
p.N986S	SIDM00282	Colorectal Carcinoma	GDSC	ARWPLPPLP	DEG_APCC_DBOX_1	0.1389
p.N986S	ACH-000998	Colon/Colorectal Cancer	CCLE	ARWPLPPLP	DEG_APCC_DBOX_1	0.1389
p.N986S	CW-2	large_intestine	COSMIC	ARWPLPPLP	DEG_APCC_DBOX_1	0.1389
p.D991G	SIDM00863	Burkitt's Lymphoma	GDSC	ARWPLPPLP	DEG_APCC_DBOX_1	0.2778
p.D991G	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	ARWPLPPLP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14654	Insulin receptor substrate 4	DEG_APCC_DBOX_1	993:1001	ARWPLPPLP	APC,CDC20,FZR1	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons