DegronMD

Uniprot ID: O14654

Source protein: Insulin receptor substrate 4

Source gene: IRS4

Class: DEG_SCF_FBW7_1

Location: 707:713

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 77.7

COIL: 0.8314

CONS_SCORE: 0.4705

DSS_SCORE: 0.5121

HELIX: 0.0289

FCONS_SCORE: 0.9298

RIG_SCORE: 0.6895

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P719S	TCGA-AJ-A3EK	UCEC	TCGA	VATPLVS	DEG_SCF_FBW7_1	0.1667
p.P719S	DO41584	UCEC	ICGC	VATPLVS	DEG_SCF_FBW7_1	0.1667
p.P722H	TCGA-B5-A3FA	UCEC	TCGA	VATPLVS	DEG_SCF_FBW7_1	0.0833
p.P722H	DO52402	UCEC	ICGC	VATPLVS	DEG_SCF_FBW7_1	0.0833
p.V701M	TCGA-FI-A2D0	UCEC	TCGA	VATPLVS	DEG_SCF_FBW7_1	0.1667
p.V701M	DO43891	UCEC	ICGC	VATPLVS	DEG_SCF_FBW7_1	0.1667
p.D698N	TCGA-YC-A8S6	BLCA	TCGA	VATPLVS	DEG_SCF_FBW7_1	0.0833
p.D698N	DO49806	BLCA	ICGC	VATPLVS	DEG_SCF_FBW7_1	0.0833
p.Y700F	DO231993	LICA	ICGC	VATPLVS	DEG_SCF_FBW7_1	0.5833
p.D697H	DO23296	LINC	ICGC	VATPLVS	DEG_SCF_FBW7_1	0.0556
p.D698H	DO224563	LUSC	ICGC	VATPLVS	DEG_SCF_FBW7_1	0.0833
p.A708V	SIDM00665	Gastric Carcinoma	GDSC	VATPLVS	DEG_SCF_FBW7_1	0.5825
p.A708V	ACH-000616	Gastric Cancer	CCLE	VATPLVS	DEG_SCF_FBW7_1	0.5825
p.A708V	Hs746T	stomach	COSMIC	VATPLVS	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14654	Insulin receptor substrate 4	DEG_SCF_FBW7_1	707:713	VATPLVS	FBXW7	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons