DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SPOP_SBC_1

Location: 19877:19881

E3 ligase: SPOP

DEGRON score: 0.7426

ASA_SCORE: 60.7

COIL: 0.5038

CONS_SCORE: 0.4813

DSS_SCORE: 0.2532

HELIX: 0.0054

FCONS_SCORE: 0.8699

RIG_SCORE: 0.7773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L19884Q	TCGA-56-1622	LUSC	TCGA	ADSSS	DEG_SPOP_SBC_1	0.25
p.P19881S	TCGA-AZ-4615	COAD	TCGA	ADSSS	DEG_SPOP_SBC_1	0.6752
p.P19881H	TCGA-DA-A1IB	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	0.7694
p.K19877T	TCGA-HU-8249	STAD	TCGA	ADSSS	DEG_SPOP_SBC_1	0.7306
p.K19877N	TCGA-L5-A4OT	ESCA	TCGA	ADSSS	DEG_SPOP_SBC_1	0.6918
p.L19883V	DO51879	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.2778
p.H19871N	DO23907	LUAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1667
p.A19873P	DO47879	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.2222
p.A19877E	DO41608	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	0.7701
p.V19874A	DO43755	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	0.25
p.E19885D	SIDM01953	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.2222
p.K19891E	SIDM00565	Oral Cavity Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.1667
p.K19891E	OSC-20	upper_aerodigestive_tract	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.1667
p.P19878S	SNU-175	large_intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.6752
p.E19873K	KYSE-510	oesophagus	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.2222
p.L19891M	KNS-62	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0MZ66	Shootin-1	DEG_SPOP_SBC_1	490:494	ADSSS	SPOP	0.992	More...
O14654	Insulin receptor substrate 4	DEG_SPOP_SBC_1	915:919	ADSSS	SPOP	0.9969	More...
O43187	Interleukin-1 receptor-associated kinase-like 2	DEG_SPOP_SBC_1	573:577	ADSSS	SPOP	0.6187	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1171:1175	ADSSS	SPOP	0.8432	More...
O95248	Myotubularin-related protein 5	DEG_SPOP_SBC_1	1235:1239	ADSSS	SPOP	0.5133	More...
P40197	Platelet glycoprotein V	DEG_SPOP_SBC_1	484:488	ADSSS	SPOP	0.6617	More...
P45973	Chromobox protein homolog 5	DEG_SPOP_SBC_1	9:13	ADSSS	SPOP	0.9016	More...
P98153	Integral membrane protein DGCR2/IDD	DEG_SPOP_SBC_1	511:515	ADSSS	SPOP	0.9946	More...
Q03468	DNA excision repair protein ERCC-6	DEG_SPOP_SBC_1	1377:1381	ADSSS	SPOP	0.9914	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	196:200	ADSSS	SPOP	0.9906	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	151:155	ADSSS	SPOP	0.9969	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	421:425	ADSSS	SPOP	0.9888	More...
Q6ZUT1	Uncharacterized protein NKAPD1	DEG_SPOP_SBC_1	181:185	ADSSS	SPOP	0.9937	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1077:1081	ADSSS	SPOP	0.9779	More...
Q86W24	NACHT, LRR and PYD domains-containing protein 14	DEG_SPOP_SBC_1	2:6	ADSSS	SPOP	0.8095	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	127:131	ADSSS	SPOP	0.8228	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19877:19881	ADSSS	SPOP	0.7426	More...
Q92834	X-linked retinitis pigmentosa GTPase regulator	DEG_SPOP_SBC_1	928:932	ADSSS	SPOP	0.9559	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	110:114	ADSSS	SPOP	0.9951	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	183:187	ADSSS	SPOP	0.9951	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	600:604	ADSSS	SPOP	0.9818	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	1055:1059	ADSSS	SPOP	0.9769	More...
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus	DEG_SPOP_SBC_1	574:578	ADSSS	SPOP	0.9639	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	82:86	ADSSS	SPOP	0.9679	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	929:933	ADSSS	SPOP	0.6557	More...
O15069	NAC-alpha domain-containing protein 1	DEG_SPOP_SBC_1	282:286	ADSSS	SPOP	0.9969	More...
Q66K14	TBC1 domain family member 9B	DEG_SPOP_SBC_1	355:359	ADSSS	SPOP	0.7361	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	494:498	ADSSS	SPOP	0.9841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADSSS

Degron related mutations and impact score

Drug responses associated with TTN mutations

All proteins holding degron of ADSSS