DegronMD - O43187(IRAK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S576F	TCGA-C5-A8XH	CESC	TCGA	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7982
p.S576F	DO49898	CESC	ICGC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7982
p.R566L	TCGA-D3-A1Q1	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1389
p.R566L	DO37445	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1389
p.E572K	TCGA-EE-A20C	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.E572K	DO222775	MELA	ICGC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.E572K	DO47665	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.S577C	TCGA-GD-A76B	BLCA	TCGA	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7541
p.S577C	DO51886	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7541
p.R566W	TCGA-R5-A7ZR	STAD	TCGA	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1389
p.R566W	DO222343	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1389
p.L565M	DO230342	COCA	ICGC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1111
p.G582C	DO228960	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1944
p.D574H	SIDM00846	Cervical Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6577
p.D574H	SIDM00285	Neuroblastoma	GDSC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6577
p.D574H	SIDM00807	Bladder Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6577
p.D574H	SIDM01318	Hepatocellular Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.6577
p.E572V	SIDM00217	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.E572V	ACH-000999	Colon/Colorectal Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.E572V	SNU-1040	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.R564K	ACH-001609	Brain Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.0833

Kaplan plot for IRAK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRAK2

UniProt ID: O43187

Entrez ID: 3656

Protein name: Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRAK2 in