DegronMD

Uniprot ID: O43187

Source protein: Interleukin-1 receptor-associated kinase-like 2

Source gene: IRAK2

Class: DEG_SPOP_SBC_1

Location: 573:577

E3 ligase: SPOP

DEGRON score: 0.6187

ASA_SCORE: 70.88

COIL: 0.7552

CONS_SCORE: 0.2835

DSS_SCORE: 0.4373

HELIX: 0.1986

FCONS_SCORE: 0.9757

RIG_SCORE: 0.6831

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S576F	TCGA-C5-A8XH	CESC	TCGA	ADSSS	DEG_SPOP_SBC_1	0.7982
p.S576F	DO49898	CESC	ICGC	ADSSS	DEG_SPOP_SBC_1	0.7982
p.R566L	TCGA-D3-A1Q1	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	0.1389
p.R566L	DO37445	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1389
p.E572K	TCGA-EE-A20C	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	0.3056
p.E572K	DO222775	MELA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.3056
p.E572K	DO47665	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	0.3056
p.S577C	TCGA-GD-A76B	BLCA	TCGA	ADSSS	DEG_SPOP_SBC_1	0.7541
p.S577C	DO51886	BLCA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.7541
p.R566W	TCGA-R5-A7ZR	STAD	TCGA	ADSSS	DEG_SPOP_SBC_1	0.1389
p.R566W	DO222343	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1389
p.L565M	DO230342	COCA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1111
p.G582C	DO228960	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	0.1944
p.D574H	SIDM00846	Cervical Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.6577
p.D574H	SIDM00285	Neuroblastoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.6577
p.D574H	SIDM00807	Bladder Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.6577
p.D574H	SIDM01318	Hepatocellular Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.6577
p.E572V	SIDM00217	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.3056
p.E572V	ACH-000999	Colon/Colorectal Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	0.3056
p.E572V	SNU-1040	large_intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.3056
p.R564K	ACH-001609	Brain Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0MZ66	Shootin-1	DEG_SPOP_SBC_1	490:494	ADSSS	SPOP	0.992	More...
O14654	Insulin receptor substrate 4	DEG_SPOP_SBC_1	915:919	ADSSS	SPOP	0.9969	More...
O43187	Interleukin-1 receptor-associated kinase-like 2	DEG_SPOP_SBC_1	573:577	ADSSS	SPOP	0.6187	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1171:1175	ADSSS	SPOP	0.8432	More...
O95248	Myotubularin-related protein 5	DEG_SPOP_SBC_1	1235:1239	ADSSS	SPOP	0.5133	More...
P40197	Platelet glycoprotein V	DEG_SPOP_SBC_1	484:488	ADSSS	SPOP	0.6617	More...
P45973	Chromobox protein homolog 5	DEG_SPOP_SBC_1	9:13	ADSSS	SPOP	0.9016	More...
P98153	Integral membrane protein DGCR2/IDD	DEG_SPOP_SBC_1	511:515	ADSSS	SPOP	0.9946	More...
Q03468	DNA excision repair protein ERCC-6	DEG_SPOP_SBC_1	1377:1381	ADSSS	SPOP	0.9914	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	196:200	ADSSS	SPOP	0.9906	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	151:155	ADSSS	SPOP	0.9969	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	421:425	ADSSS	SPOP	0.9888	More...
Q6ZUT1	Uncharacterized protein NKAPD1	DEG_SPOP_SBC_1	181:185	ADSSS	SPOP	0.9937	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1077:1081	ADSSS	SPOP	0.9779	More...
Q86W24	NACHT, LRR and PYD domains-containing protein 14	DEG_SPOP_SBC_1	2:6	ADSSS	SPOP	0.8095	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	127:131	ADSSS	SPOP	0.8228	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19877:19881	ADSSS	SPOP	0.7426	More...
Q92834	X-linked retinitis pigmentosa GTPase regulator	DEG_SPOP_SBC_1	928:932	ADSSS	SPOP	0.9559	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	110:114	ADSSS	SPOP	0.9951	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	183:187	ADSSS	SPOP	0.9951	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	600:604	ADSSS	SPOP	0.9818	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	1055:1059	ADSSS	SPOP	0.9769	More...
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus	DEG_SPOP_SBC_1	574:578	ADSSS	SPOP	0.9639	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	82:86	ADSSS	SPOP	0.9679	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	929:933	ADSSS	SPOP	0.6557	More...
O15069	NAC-alpha domain-containing protein 1	DEG_SPOP_SBC_1	282:286	ADSSS	SPOP	0.9969	More...
Q66K14	TBC1 domain family member 9B	DEG_SPOP_SBC_1	355:359	ADSSS	SPOP	0.7361	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	494:498	ADSSS	SPOP	0.9841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADSSS

Degron related mutations and impact score

Drug responses associated with IRAK2 mutations

All proteins holding degron of ADSSS