DegronMD - O15069(NACAD)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S281C	TCGA-5L-AAT1	BRCA	TCGA	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.S281C	DO219594	BRCA	ICGC	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.Q1289H	TCGA-A5-A0G1	UCEC	TCGA	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.0833
p.Q1289H	DO42472	UCEC	ICGC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.0833
p.A1281T	TCGA-A5-A0G1	UCEC	TCGA	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.A1281T	DO233732	GACA	ICGC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.A1281T	DO42472	UCEC	ICGC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.A1281T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.A1281T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.A1281T	ACH-000953	Leukemia	CCLE	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.A1281T	ACH-001127	Leukemia	CCLE	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.A1281T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.A1281T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.3056
p.S554R	TCGA-AJ-A3TW	UCEC	TCGA	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.2778
p.S554R	DO43723	UCEC	ICGC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.2778
p.E408D	TCGA-AP-A059	UCEC	TCGA	DDERLYSGEP	CBL_PTK	400:409	Mutation altering degron motif	0.5647
p.E408D	DO41361	UCEC	ICGC	DDERLYSGEP	CBL_PTK	400:409	Mutation altering degron motif	0.5647
p.R39Q	TCGA-AX-A3FT	UCEC	TCGA	LTPGPS	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.1667
p.R39Q	DO40801	UCEC	ICGC	LTPGPS	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.1667
p.E154K	TCGA-BK-A6W3	UCEC	TCGA	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation rewiring degron network	0.25
p.E154K	DO50076	UCEC	ICGC	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation rewiring degron network	0.25
p.P409S	TCGA-DD-A3A7	LIHC	TCGA	DDERLYSGEP	CBL_PTK	400:409	Mutation altering degron motif	0.6752
p.P409S	DO44982	LIHC	ICGC	DDERLYSGEP	CBL_PTK	400:409	Mutation altering degron motif	0.6752
p.Q1289R	TCGA-EO-A22U	UCEC	TCGA	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.0833
p.Q1289R	DO43755	UCEC	ICGC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.0833
p.S162Y	TCGA-EO-A3B0	UCEC	TCGA	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation altering degron motif	0.6009
p.S162Y	DO219773	UCEC	ICGC	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation altering degron motif	0.6009
p.G407E	TCGA-G4-6320	COAD	TCGA	DDERLYSGEP	CBL_PTK	400:409	Mutation altering degron motif	0.6087
p.G407E	DO8159	COAD	ICGC	DDERLYSGEP	CBL_PTK	400:409	Mutation altering degron motif	0.6087
p.S276C	TCGA-PK-A5HB	ACC	TCGA	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.S276C	ACH-000945	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.P1279R	DO228750	GACA	ICGC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation altering degron motif	0.7512
p.A543V	DO233652	GACA	ICGC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.25
p.D392N	DO233622	GACA	ICGC	DDERLYSGEP	CBL_PTK	400:409	Mutation rewiring degron network	0.1111
p.D392N	DO222710	MELA	ICGC	DDERLYSGEP	CBL_PTK	400:409	Mutation rewiring degron network	0.1111
p.T548P	DO230659	LAML	ICGC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation altering degron motif	0.7031
p.T548P	DO231140	LAML	ICGC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation altering degron motif	0.7031
p.T548P	ACH-001100		CCLE	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation altering degron motif	0.7031
p.T548P	ACH-002313	Lymphoma	CCLE	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation altering degron motif	0.7031
p.T548P	TK	haematopoietic and lymphoid tissue	COSMIC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation altering degron motif	0.7031
p.A543E	DO229018	LICA	ICGC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.25
p.T179N	DO229037	LICA	ICGC	PPSTPTKT	DEG_SCF_FBW7_1	176:183	Mutation altering degron motif	0.7055
p.P273T	DO229006	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0833
p.G1266S	DO50970	LICA	ICGC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.1667
p.D401Y	DO23238	LINC	ICGC	DDERLYSGEP	CBL_PTK	400:409	Mutation altering degron motif	0.6214
p.F174L	DO25040	LUAD	ICGC	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation rewiring degron network	0.1111
p.F174L	DO25040	LUAD	ICGC	PPSTPTKT	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.2778
p.A147T	DO231075	LUSC	ICGC	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation rewiring degron network	0.0556
p.P189L	DO222434	MELA	ICGC	PPSTPTKT	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1667
p.P177L	DO222837	MELA	ICGC	PPSTPTKT	DEG_SCF_FBW7_1	176:183	Mutation altering degron motif	0.6471
p.R40W	DO38831	STAD	ICGC	LTPGPS	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.1944
p.D169Y	SIDM00572	Gastric Carcinoma	GDSC	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation rewiring degron network	0.25
p.D169Y	SIDM00572	Gastric Carcinoma	GDSC	PPSTPTKT	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1389
p.D169Y	ACH-000911	Gastric Cancer	CCLE	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation rewiring degron network	0.25
p.D169Y	ACH-000911	Gastric Cancer	CCLE	PPSTPTKT	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1389
p.P164H	SIDM00216	Colorectal Carcinoma	GDSC	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation altering degron motif	0.7694
p.S285G	SIDM00633	Breast Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6993
p.S285G	SIDM00210	Ovarian Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6993
p.S285G	SIDM00621	Ewing's Sarcoma	GDSC	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6993
p.S285G	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6993
p.P562S	SIDM00007	Other Solid Cancers	GDSC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.0556
p.P562S	ACH-001550	Skin Cancer	CCLE	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.0556
p.P562S	MCC13	skin	COSMIC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.0556
p.Q290H	SIDM00465	Ovarian Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.Q290H	ACH-002183	Ovarian Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.Q290H	OVMIU	ovary	COSMIC	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.A1283S	SIDM00761	Small Cell Lung Carcinoma	GDSC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.25
p.A1283S	ACH-000752	Lung Cancer	CCLE	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.25
p.A394V	SIDM00616	Hepatocellular Carcinoma	GDSC	DDERLYSGEP	CBL_PTK	400:409	Mutation rewiring degron network	0.1667
p.A394V	ACH-000543	Brain Cancer	CCLE	DDERLYSGEP	CBL_PTK	400:409	Mutation rewiring degron network	0.1667
p.A394V	JHH-4	liver	COSMIC	DDERLYSGEP	CBL_PTK	400:409	Mutation rewiring degron network	0.1667
p.A1283T	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.25
p.A1283T	ACH-000865	Esophageal Cancer	CCLE	PPQAGVQPA	DEG_SIAH_1	1272:1280	Mutation rewiring degron network	0.25
p.S395F	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DDERLYSGEP	CBL_PTK	400:409	Mutation rewiring degron network	0.1944
p.S395F	ACH-002222	Leukemia	CCLE	DDERLYSGEP	CBL_PTK	400:409	Mutation rewiring degron network	0.1944
p.S395F	CTV-1	haematopoietic and lymphoid tissue	COSMIC	DDERLYSGEP	CBL_PTK	400:409	Mutation rewiring degron network	0.1944
p.S540F	SIDM00937	Oral Cavity Carcinoma	GDSC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.1667
p.S540F	CAL-27	upper aerodigestive tract	COSMIC	LPTPQEE	DEG_SCF_FBW7_2	546:552	Mutation rewiring degron network	0.1667
p.G289C	ACH-000559	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.25
p.S165F	ACH-000810	Skin Cancer	CCLE	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation altering degron motif	0.7982
p.P170L	ACH-001610	Brain Cancer	CCLE	SQGDLSVPSP	DEG_COP1_1	157:166	Mutation rewiring degron network	0.2222
p.P170L	ACH-001610	Brain Cancer	CCLE	PPSTPTKT	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NACAD

UniProt ID: O15069

Entrez ID: 23148

Protein name: NAC-alpha domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NACAD in