DegronMD

Uniprot ID: O15069

Source protein: NAC-alpha domain-containing protein 1

Source gene: NACAD

Class: CBL_PTK

Location: 400:409

E3 ligase: CBL

DEGRON score: 0.9925

ASA_SCORE: 91.7

COIL: 0.7261

CONS_SCORE: 0.4839

DSS_SCORE: 0.6381

HELIX: 0.2488

FCONS_SCORE: 1.2291

RIG_SCORE: 0.6734

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P409S	TCGA-DD-A3A7	LIHC	TCGA	DDERLYSGEP	CBL_PTK	0.6752
p.P409S	DO44982	LIHC	ICGC	DDERLYSGEP	CBL_PTK	0.6752
p.D401Y	DO23238	LINC	ICGC	DDERLYSGEP	CBL_PTK	0.6214
p.G407E	TCGA-G4-6320	COAD	TCGA	DDERLYSGEP	CBL_PTK	0.6087
p.G407E	DO8159	COAD	ICGC	DDERLYSGEP	CBL_PTK	0.6087
p.E408D	TCGA-AP-A059	UCEC	TCGA	DDERLYSGEP	CBL_PTK	0.5647
p.E408D	DO41361	UCEC	ICGC	DDERLYSGEP	CBL_PTK	0.5647
p.S395F	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DDERLYSGEP	CBL_PTK	0.1944
p.S395F	ACH-002222	Leukemia	CCLE	DDERLYSGEP	CBL_PTK	0.1944
p.S395F	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DDERLYSGEP	CBL_PTK	0.1944
p.A394V	SIDM00616	Hepatocellular Carcinoma	GDSC	DDERLYSGEP	CBL_PTK	0.1667
p.A394V	ACH-000543	Brain Cancer	CCLE	DDERLYSGEP	CBL_PTK	0.1667
p.A394V	JHH-4	liver	COSMIC	DDERLYSGEP	CBL_PTK	0.1667
p.D392N	DO233622	GACA	ICGC	DDERLYSGEP	CBL_PTK	0.1111
p.D392N	DO222710	MELA	ICGC	DDERLYSGEP	CBL_PTK	0.1111

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15069	NAC-alpha domain-containing protein 1	CBL_PTK	400:409	DDERLYSGEP	CBL	0.9925	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons