DegronMD

Uniprot ID: O15069

Source protein: NAC-alpha domain-containing protein 1

Source gene: NACAD

Class: DEG_SCF_FBW7_1

Location: 176:183

E3 ligase: FBXW7

DEGRON score: 0.9586

ASA_SCORE: 93.5875

COIL: 0.956

CONS_SCORE: 0.3928

DSS_SCORE: 0.6196

HELIX: 0.0169

FCONS_SCORE: 1.0792

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T179N	DO229037	LICA	ICGC	PPSTPTKT	DEG_SCF_FBW7_1	0.7055
p.F174L	DO25040	LUAD	ICGC	PPSTPTKT	DEG_SCF_FBW7_1	0.2778
p.P189L	DO222434	MELA	ICGC	PPSTPTKT	DEG_SCF_FBW7_1	0.1667
p.P177L	DO222837	MELA	ICGC	PPSTPTKT	DEG_SCF_FBW7_1	0.6471
p.D169Y	SIDM00572	Gastric Carcinoma	GDSC	PPSTPTKT	DEG_SCF_FBW7_1	0.1389
p.D169Y	ACH-000911	Gastric Cancer	CCLE	PPSTPTKT	DEG_SCF_FBW7_1	0.1389
p.P170L	ACH-001610	Brain Cancer	CCLE	PPSTPTKT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15069	NAC-alpha domain-containing protein 1	DEG_SCF_FBW7_1	176:183	PPSTPTKT	FBXW7	0.9586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons