DegronMD

Uniprot ID: O15069

Source protein: NAC-alpha domain-containing protein 1

Source gene: NACAD

Class: DEG_SCF_FBW7_2

Location: 546:552

E3 ligase: FBXW7

DEGRON score: 0.959

ASA_SCORE: 105.0143

COIL: 0.9143

CONS_SCORE: 0.3287

DSS_SCORE: 0.6635

HELIX: 0.0626

FCONS_SCORE: 0.92

RIG_SCORE: 0.6684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S554R	TCGA-AJ-A3TW	UCEC	TCGA	LPTPQEE	DEG_SCF_FBW7_2	0.2778
p.S554R	DO43723	UCEC	ICGC	LPTPQEE	DEG_SCF_FBW7_2	0.2778
p.A543V	DO233652	GACA	ICGC	LPTPQEE	DEG_SCF_FBW7_2	0.25
p.T548P	DO230659	LAML	ICGC	LPTPQEE	DEG_SCF_FBW7_2	0.7031
p.T548P	DO231140	LAML	ICGC	LPTPQEE	DEG_SCF_FBW7_2	0.7031
p.T548P	ACH-001100		CCLE	LPTPQEE	DEG_SCF_FBW7_2	0.7031
p.T548P	ACH-002313	Lymphoma	CCLE	LPTPQEE	DEG_SCF_FBW7_2	0.7031
p.T548P	TK	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPQEE	DEG_SCF_FBW7_2	0.7031
p.A543E	DO229018	LICA	ICGC	LPTPQEE	DEG_SCF_FBW7_2	0.25
p.P562S	SIDM00007	Other Solid Cancers	GDSC	LPTPQEE	DEG_SCF_FBW7_2	0.0556
p.P562S	ACH-001550	Skin Cancer	CCLE	LPTPQEE	DEG_SCF_FBW7_2	0.0556
p.P562S	MCC13	skin	COSMIC	LPTPQEE	DEG_SCF_FBW7_2	0.0556
p.S540F	SIDM00937	Oral Cavity Carcinoma	GDSC	LPTPQEE	DEG_SCF_FBW7_2	0.1667
p.S540F	CAL-27	upper_aerodigestive_tract	COSMIC	LPTPQEE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15069	NAC-alpha domain-containing protein 1	DEG_SCF_FBW7_2	546:552	LPTPQEE	FBXW7	0.959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons