DegronMD

Uniprot ID: O15069

Source protein: NAC-alpha domain-containing protein 1

Source gene: NACAD

Class: DEG_SCF_FBW7_1

Location: 45:50

E3 ligase: FBXW7

DEGRON score: 0.9877

ASA_SCORE: 77.8833

COIL: 0.9412

CONS_SCORE: 0.3192

DSS_SCORE: 0.5062

HELIX: 0.0263

FCONS_SCORE: 1.0565

RIG_SCORE: 0.6565

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R40W	DO38831	STAD	ICGC	LTPGPS	DEG_SCF_FBW7_1	0.1944
p.R39Q	TCGA-AX-A3FT	UCEC	TCGA	LTPGPS	DEG_SCF_FBW7_1	0.1667
p.R39Q	DO40801	UCEC	ICGC	LTPGPS	DEG_SCF_FBW7_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15069	NAC-alpha domain-containing protein 1	DEG_SCF_FBW7_1	45:50	LTPGPS	FBXW7	0.9877	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons