DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPGPS
Uniprot ID:
O15069
Source protein:
NAC-alpha domain-containing protein 1
Source gene:
NACAD
Class:
DEG_SCF_FBW7_1
Location:
45:50
E3 ligase:
FBXW7
DEGRON score:
0.9877
ASA_SCORE:
77.8833
COIL:
0.9412
CONS_SCORE:
0.3192
DSS_SCORE:
0.5062
HELIX:
0.0263
FCONS_SCORE:
1.0565
RIG_SCORE:
0.6565
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R39Q
TCGA-AX-A3FT
UCEC
TCGA
LTPGPS
DEG_SCF_FBW7_1
0.1667
p.R39Q
DO40801
UCEC
ICGC
LTPGPS
DEG_SCF_FBW7_1
0.1667
p.R40W
DO38831
STAD
ICGC
LTPGPS
DEG_SCF_FBW7_1
0.1944
Drug responses associated with NACAD mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPGPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15069
NAC-alpha domain-containing protein 1
DEG_SCF_FBW7_1
45:50
LTPGPS
FBXW7
0.9877
More...