DegronMD

Uniprot ID: O15069

Source protein: NAC-alpha domain-containing protein 1

Source gene: NACAD

Class: DEG_COP1_1

Location: 157:166

E3 ligase: COP1

DEGRON score: 0.9961

ASA_SCORE: 86.37

COIL: 0.9651

CONS_SCORE: 0.447

DSS_SCORE: 0.7952

HELIX: 0.0147

FCONS_SCORE: 1.184

RIG_SCORE: 0.5446

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E154K	TCGA-BK-A6W3	UCEC	TCGA	SQGDLSVPSP	DEG_COP1_1	0.25
p.E154K	DO50076	UCEC	ICGC	SQGDLSVPSP	DEG_COP1_1	0.25
p.S162Y	TCGA-EO-A3B0	UCEC	TCGA	SQGDLSVPSP	DEG_COP1_1	0.6009
p.S162Y	DO219773	UCEC	ICGC	SQGDLSVPSP	DEG_COP1_1	0.6009
p.F174L	DO25040	LUAD	ICGC	SQGDLSVPSP	DEG_COP1_1	0.1111
p.A147T	DO231075	LUSC	ICGC	SQGDLSVPSP	DEG_COP1_1	0.0556
p.D169Y	SIDM00572	Gastric Carcinoma	GDSC	SQGDLSVPSP	DEG_COP1_1	0.25
p.D169Y	ACH-000911	Gastric Cancer	CCLE	SQGDLSVPSP	DEG_COP1_1	0.25
p.P164H	SIDM00216	Colorectal Carcinoma	GDSC	SQGDLSVPSP	DEG_COP1_1	0.7694
p.S165F	ACH-000810	Skin Cancer	CCLE	SQGDLSVPSP	DEG_COP1_1	0.7982
p.P170L	ACH-001610	Brain Cancer	CCLE	SQGDLSVPSP	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15069	NAC-alpha domain-containing protein 1	DEG_COP1_1	157:166	SQGDLSVPSP	COP1	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons