DegronMD

Uniprot ID: O15069

Source protein: NAC-alpha domain-containing protein 1

Source gene: NACAD

Class: DEG_SIAH_1

Location: 1272:1280

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7377

ASA_SCORE: 83.0778

COIL: 0.92

CONS_SCORE: 0.2925

DSS_SCORE: 0.7018

HELIX: 0.0496

FCONS_SCORE: 0.9657

RIG_SCORE: 0.617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1289H	TCGA-A5-A0G1	UCEC	TCGA	PPQAGVQPA	DEG_SIAH_1	0.0833
p.Q1289H	DO42472	UCEC	ICGC	PPQAGVQPA	DEG_SIAH_1	0.0833
p.A1281T	TCGA-A5-A0G1	UCEC	TCGA	PPQAGVQPA	DEG_SIAH_1	0.3056
p.A1281T	DO233732	GACA	ICGC	PPQAGVQPA	DEG_SIAH_1	0.3056
p.A1281T	DO42472	UCEC	ICGC	PPQAGVQPA	DEG_SIAH_1	0.3056
p.A1281T	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPQAGVQPA	DEG_SIAH_1	0.3056
p.A1281T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPQAGVQPA	DEG_SIAH_1	0.3056
p.A1281T	ACH-000953	Leukemia	CCLE	PPQAGVQPA	DEG_SIAH_1	0.3056
p.A1281T	ACH-001127	Leukemia	CCLE	PPQAGVQPA	DEG_SIAH_1	0.3056
p.A1281T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPQAGVQPA	DEG_SIAH_1	0.3056
p.A1281T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPQAGVQPA	DEG_SIAH_1	0.3056
p.Q1289R	TCGA-EO-A22U	UCEC	TCGA	PPQAGVQPA	DEG_SIAH_1	0.0833
p.Q1289R	DO43755	UCEC	ICGC	PPQAGVQPA	DEG_SIAH_1	0.0833
p.P1279R	DO228750	GACA	ICGC	PPQAGVQPA	DEG_SIAH_1	0.7512
p.G1266S	DO50970	LICA	ICGC	PPQAGVQPA	DEG_SIAH_1	0.1667
p.A1283S	SIDM00761	Small Cell Lung Carcinoma	GDSC	PPQAGVQPA	DEG_SIAH_1	0.25
p.A1283S	ACH-000752	Lung Cancer	CCLE	PPQAGVQPA	DEG_SIAH_1	0.25
p.A1283T	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PPQAGVQPA	DEG_SIAH_1	0.25
p.A1283T	ACH-000865	Esophageal Cancer	CCLE	PPQAGVQPA	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15069	NAC-alpha domain-containing protein 1	DEG_SIAH_1	1272:1280	PPQAGVQPA	SIAH1,SIAH2,SIAH3	0.7377	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons