DegronMD - Q92834(RPGR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S418Y	TCGA-AP-A051	UCEC	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation blocking phosphorylation signal	0.6111
p.T434I	TCGA-B5-A3FC	UCEC	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.2778
p.S421P	TCGA-D8-A1XY	BRCA	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.25
p.S438C	TCGA-DK-A3IQ	BLCA	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.1667
p.S418F	TCGA-EO-A1Y8	UCEC	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation blocking phosphorylation signal	0.6111
p.T441K	DO52299	LIHC	ICGC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.0833
p.E934G	DO23296	LINC	ICGC	ADSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2778
p.E934G	DO23278	LINC	ICGC	ADSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2778
p.E934G	DO23172	LINC	ICGC	ADSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2778
p.E936D	DO23278	LINC	ICGC	ADSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2222
p.G919E	DO23196	LINC	ICGC	ADSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0833
p.G432R	DO23555	LUAD	ICGC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation altering degron motif	0.7568
p.D423G	DO42033	UCEC	ICGC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.3056
p.S425Y	DO42312	UCEC	ICGC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation altering degron motif	0.712
p.S421Y	SIDM00193	Colorectal Carcinoma	GDSC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.25
p.S421Y	ACH-000991	Colon/Colorectal Cancer	CCLE	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.25
p.S421Y	SNU-81	large intestine	COSMIC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.25
p.E432D	SIDM00210	Ovarian Carcinoma	GDSC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation altering degron motif	0.5647
p.E432D	SIDM00068	Colorectal Carcinoma	GDSC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation altering degron motif	0.5647
p.S421C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.25
p.S421C	ACH-000309	Lung Cancer	CCLE	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.25
p.S421C	SK-LU-1	lung	COSMIC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.25
p.N919D	ACH-000467	Colon/Colorectal Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0833
p.N919D	HCC-56	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0833
p.E433K	NCI-H2110	lung	COSMIC	MRRTLPPIE	DEG_APCC_DBOX_1	424:432	Mutation rewiring degron network	0.3056

Kaplan plot for RPGR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPGR

UniProt ID: Q92834

Entrez ID: 6103

Protein name: X-linked retinitis pigmentosa GTPase regulator

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPGR in