DegronMD

Uniprot ID: Q92834

Source protein: X-linked retinitis pigmentosa GTPase regulator

Source gene: RPGR

Class: DEG_APCC_DBOX_1

Location: 424:432

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 75.3222

COIL: 0.7109

CONS_SCORE: 0.3674

DSS_SCORE: 0.4505

HELIX: 0.1019

FCONS_SCORE: 1.1075

RIG_SCORE: 0.7063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S418Y	TCGA-AP-A051	UCEC	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	0.6111
p.T434I	TCGA-B5-A3FC	UCEC	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	0.2778
p.S421P	TCGA-D8-A1XY	BRCA	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	0.25
p.S438C	TCGA-DK-A3IQ	BLCA	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	0.1667
p.S418F	TCGA-EO-A1Y8	UCEC	TCGA	MRRTLPPIE	DEG_APCC_DBOX_1	0.6111
p.T441K	DO52299	LIHC	ICGC	MRRTLPPIE	DEG_APCC_DBOX_1	0.0833
p.G432R	DO23555	LUAD	ICGC	MRRTLPPIE	DEG_APCC_DBOX_1	0.7568
p.D423G	DO42033	UCEC	ICGC	MRRTLPPIE	DEG_APCC_DBOX_1	0.3056
p.S425Y	DO42312	UCEC	ICGC	MRRTLPPIE	DEG_APCC_DBOX_1	0.712
p.S421Y	SIDM00193	Colorectal Carcinoma	GDSC	MRRTLPPIE	DEG_APCC_DBOX_1	0.25
p.S421Y	ACH-000991	Colon/Colorectal Cancer	CCLE	MRRTLPPIE	DEG_APCC_DBOX_1	0.25
p.S421Y	SNU-81	large_intestine	COSMIC	MRRTLPPIE	DEG_APCC_DBOX_1	0.25
p.E432D	SIDM00210	Ovarian Carcinoma	GDSC	MRRTLPPIE	DEG_APCC_DBOX_1	0.5647
p.E432D	SIDM00068	Colorectal Carcinoma	GDSC	MRRTLPPIE	DEG_APCC_DBOX_1	0.5647
p.S421C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	MRRTLPPIE	DEG_APCC_DBOX_1	0.25
p.S421C	ACH-000309	Lung Cancer	CCLE	MRRTLPPIE	DEG_APCC_DBOX_1	0.25
p.S421C	SK-LU-1	lung	COSMIC	MRRTLPPIE	DEG_APCC_DBOX_1	0.25
p.E433K	NCI-H2110	lung	COSMIC	MRRTLPPIE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92834	X-linked retinitis pigmentosa GTPase regulator	DEG_APCC_DBOX_1	424:432	MRRTLPPIE	APC,CDC20,FZR1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons