DegronMD

Uniprot ID: Q9UKV3

Source protein: Apoptotic chromatin condensation inducer in the nucleus

Source gene: ACIN1

Class: DEG_MDM2_SWIB_1

Location: 35:42

E3 ligase: MDM2

DEGRON score: 0.6731

ASA_SCORE: 76.1875

COIL: 0.5404

CONS_SCORE: 0.1999

DSS_SCORE: 0.4995

HELIX: 0.0591

FCONS_SCORE: 1.0667

RIG_SCORE: 0.7686

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G37E	TCGA-55-8301	LUAD	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	0.6087
p.G37E	DO24682	LUAD	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.6087
p.P43Q	TCGA-55-8615	LUAD	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	0.3056
p.P43Q	DO24665	LUAD	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.3056
p.A48S	TCGA-BR-7851	STAD	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	0.1667
p.A48S	DO38711	STAD	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.1667
p.L32I	TCGA-EO-A22X	UCEC	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	0.25
p.L32I	DO43907	UCEC	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.25
p.R40L	TCGA-GI-A2C8	BRCA	TCGA	FEGRWRKL	DEG_MDM2_SWIB_1	0.7316
p.R40L	DO5992	BRCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.7316
p.M32V	DO225346	BRCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.25
p.H31Y	DO222606	BTCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.2222
p.H31Y	SIDM01608	Endometrial Carcinoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	0.2222
p.H31Y	ACH-000990	Endometrial/Uterine Cancer	CCLE	FEGRWRKL	DEG_MDM2_SWIB_1	0.2222
p.Y25C	DO227987	COCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.0556
p.P44L	DO227996	COCA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.2778
p.R38S	DO229026	LICA	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.6316
p.P39S	DO42033	UCEC	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.6752
p.P33H	DO42608	UCEC	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.2778
p.P31S	DO43755	UCEC	ICGC	FEGRWRKL	DEG_MDM2_SWIB_1	0.2222
p.G28R	SIDM01197	Colorectal Carcinoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	0.1389
p.G28R	ACH-000722	Colon/Colorectal Cancer	CCLE	FEGRWRKL	DEG_MDM2_SWIB_1	0.1389
p.G28R	SNU-C1	large_intestine	COSMIC	FEGRWRKL	DEG_MDM2_SWIB_1	0.1389
p.A48V	SIDM00789	Colorectal Carcinoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	0.1667
p.A48V	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	0.1667
p.E47K	SIDM00150	Colorectal Carcinoma	GDSC	FEGRWRKL	DEG_MDM2_SWIB_1	0.1944
p.R43Q	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	FEGRWRKL	DEG_MDM2_SWIB_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FEGRWRKL

Degron related mutations and impact score

Drug responses associated with ACIN1 mutations

All proteins holding degron of FEGRWRKL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus	DEG_MDM2_SWIB_1	35:42	FEGRWRKL	MDM2	0.6731	More...