DegronMD

Uniprot ID: Q9HCJ0

Source protein: Trinucleotide repeat-containing gene 6C protein

Source gene: TNRC6C

Class: DEG_COP1_1

Location: 1408:1418

E3 ligase: COP1

DEGRON score: 0.9988

ASA_SCORE: 74.8091

COIL: 0.939

CONS_SCORE: 0.6552

DSS_SCORE: 0.6724

HELIX: 0.0164

FCONS_SCORE: 1.2769

RIG_SCORE: 0.6514

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1428I	TCGA-AX-A0J1	UCEC	TCGA	DVTPGSVPTGP	DEG_COP1_1	0.0556
p.L1428I	DO41199	UCEC	ICGC	DVTPGSVPTGP	DEG_COP1_1	0.0556
p.V1406I	TCGA-D3-A8GC	SKCM	TCGA	DVTPGSVPTGP	DEG_COP1_1	0.2778
p.V1406I	DO50281	SKCM	ICGC	DVTPGSVPTGP	DEG_COP1_1	0.2778
p.P1415R	TCGA-UZ-A9PN	KIRP	TCGA	DVTPGSVPTGP	DEG_COP1_1	0.7512
p.P1415R	DO219703	KIRP	ICGC	DVTPGSVPTGP	DEG_COP1_1	0.7512
p.V1411I	DO233126	GACA	ICGC	DVTPGSVPTGP	DEG_COP1_1	0.7076
p.E1401V	DO27959	ORCA	ICGC	DVTPGSVPTGP	DEG_COP1_1	0.1389
p.T1420A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DVTPGSVPTGP	DEG_COP1_1	0.2778
p.T1420A	ACH-000914	Lymphoma	CCLE	DVTPGSVPTGP	DEG_COP1_1	0.2778
p.T1420A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	DVTPGSVPTGP	DEG_COP1_1	0.2778
p.T1423A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	DVTPGSVPTGP	DEG_COP1_1	0.1944
p.K1428E	LNCaP-Clone-FGC	prostate	COSMIC	DVTPGSVPTGP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_COP1_1	1408:1418	DVTPGSVPTGP	COP1	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons