DegronMD - Q15311(RALBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R16H	TCGA-2W-A8YY	CESC	TCGA	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.1111
p.R16H	TCGA-2W-A8YY	CESC	TCGA	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.R16H	DO223732	CESC	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.1111
p.R16H	DO223732	CESC	ICGC	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.R26Q	TCGA-A5-A1OF	UCEC	TCGA	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation altering degron motif	0.6218
p.R26Q	DO42568	UCEC	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation altering degron motif	0.6218
p.R26Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation altering degron motif	0.6218
p.R26Q	ACH-000938	Leukemia	CCLE	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation altering degron motif	0.6218
p.R26Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation altering degron motif	0.6218
p.P12H	TCGA-AP-A059	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.P12H	DO41361	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.E14G	TCGA-D1-A103	UCEC	TCGA	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.0556
p.E14G	TCGA-D1-A103	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.E14G	DO42312	UCEC	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.0556
p.E14G	DO42312	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.P35H	TCGA-D3-A2JG	SKCM	TCGA	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.2222
p.P35H	DO47613	SKCM	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.2222
p.S10I	DO229035	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7341
p.G23R	DO51549	PACA	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.3056
p.G23R	SIDM01045	Endometrial Carcinoma	GDSC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.3056
p.G23R	ACH-000978	Endometrial/Uterine Cancer	CCLE	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.3056
p.G23R	EN	endometrium	COSMIC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.3056
p.H15Y	SIDM00241	Breast Carcinoma	GDSC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.0833
p.H15Y	SIDM00241	Breast Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.H15Y	ACH-002179	Breast Cancer	CCLE	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.0833
p.H15Y	ACH-002179	Breast Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.H15Y	OCUB-M	breast	COSMIC	LTRTPSSE	DEG_SCF_FBW7_2	24:31	Mutation rewiring degron network	0.0833
p.H15Y	OCUB-M	breast	COSMIC	PPTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222

Kaplan plot for RALBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RALBP1

UniProt ID: Q15311

Entrez ID: 10928

Protein name: RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2) (EC 7.6.2.3) (Ral-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RALBP1 in