DegronMD

Uniprot ID: Q15311

Source protein: RalA-binding protein 1

Source gene: RALBP1

Class: DEG_SCF_FBW7_2

Location: 24:31

E3 ligase: FBXW7

DEGRON score: 0.9284

ASA_SCORE: 95.975

COIL: 0.8698

CONS_SCORE: 0.3177

DSS_SCORE: 0.709

HELIX: 0.0978

FCONS_SCORE: 1.0164

RIG_SCORE: 0.5889

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R16H	TCGA-2W-A8YY	CESC	TCGA	LTRTPSSE	DEG_SCF_FBW7_2	0.1111
p.R16H	DO223732	CESC	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	0.1111
p.R26Q	TCGA-A5-A1OF	UCEC	TCGA	LTRTPSSE	DEG_SCF_FBW7_2	0.6218
p.R26Q	DO42568	UCEC	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	0.6218
p.R26Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LTRTPSSE	DEG_SCF_FBW7_2	0.6218
p.R26Q	ACH-000938	Leukemia	CCLE	LTRTPSSE	DEG_SCF_FBW7_2	0.6218
p.R26Q	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LTRTPSSE	DEG_SCF_FBW7_2	0.6218
p.E14G	TCGA-D1-A103	UCEC	TCGA	LTRTPSSE	DEG_SCF_FBW7_2	0.0556
p.E14G	DO42312	UCEC	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	0.0556
p.P35H	TCGA-D3-A2JG	SKCM	TCGA	LTRTPSSE	DEG_SCF_FBW7_2	0.2222
p.P35H	DO47613	SKCM	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	0.2222
p.G23R	DO51549	PACA	ICGC	LTRTPSSE	DEG_SCF_FBW7_2	0.3056
p.G23R	SIDM01045	Endometrial Carcinoma	GDSC	LTRTPSSE	DEG_SCF_FBW7_2	0.3056
p.G23R	ACH-000978	Endometrial/Uterine Cancer	CCLE	LTRTPSSE	DEG_SCF_FBW7_2	0.3056
p.G23R	EN	endometrium	COSMIC	LTRTPSSE	DEG_SCF_FBW7_2	0.3056
p.H15Y	SIDM00241	Breast Carcinoma	GDSC	LTRTPSSE	DEG_SCF_FBW7_2	0.0833
p.H15Y	ACH-002179	Breast Cancer	CCLE	LTRTPSSE	DEG_SCF_FBW7_2	0.0833
p.H15Y	OCUB-M	breast	COSMIC	LTRTPSSE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15311	RalA-binding protein 1	DEG_SCF_FBW7_2	24:31	LTRTPSSE	FBXW7	0.9284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons