DegronMD

Uniprot ID: P52333

Source protein: Tyrosine-protein kinase JAK3

Source gene: JAK3

Class: DEG_SPOP_SBC_1

Location: 494:498

E3 ligase: SPOP

DEGRON score: 0.8529

ASA_SCORE: 77.44

COIL: 0.8982

CONS_SCORE: 0.3318

DSS_SCORE: 0.5365

HELIX: 0.0642

FCONS_SCORE: 0.7909

RIG_SCORE: 0.6265

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S493C	TCGA-17-Z016	LUAD	TCGA	PPTSS	DEG_SPOP_SBC_1	0.3056
p.S493R	TCGA-37-5819	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.3056
p.S493R	DO26479	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.3056
p.Q507R	TCGA-50-5049	LUAD	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0833
p.Q507R	DO23705	LUAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.Q507H	TCGA-90-A59Q	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0833
p.Q507H	DO50103	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.G491C	TCGA-B5-A3FA	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.25
p.G491C	DO52402	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.Q507L	TCGA-CN-5360	HNSC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0833
p.Q507L	DO14662	HNSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.Q489H	TCGA-D8-A1J9	BRCA	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1944
p.Q489H	DO2067	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.Q505K	DO229032	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1389
p.Q501K	DO229006	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.S498F	DO222521	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.9093
p.S504C	SIDM00864	Cervical Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.S504C	ACH-001341	Cervical Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.1667
p.S504C	DoTc2-4510	cervix	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.Q501H	SIDM01774	Pancreatic Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.25
p.Q501H	ACH-000205	Pancreatic Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.25
p.Q501H	ACH-002042	Thyroid Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.25

Drug responses associated with JAK3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00087	MM\|myeloma	p.S789L (No)	GDSC	WHI-P97	49.6166
SIDM00087	MM\|myeloma	p.S789L (No)	GDSC	JAK3_7406	14.4482
SIDM00087	MM\|myeloma	p.S789L (No)	GDSC	AZ960	1.1402
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.P725S (No)	GDSC	WHI-P97	24.3951
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.P725S (No)	GDSC	JAK3_7406	7.8535
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.P725S (No)	GDSC	AZ960	2.5743
SIDM00151	OV\|ovary	p.M937T (No)	GDSC	JAK3_7406	15.6927
SIDM00151	OV\|ovary	p.M937T (No)	GDSC	AZ960	2.8363
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.L1017M (No)	GDSC	WHI-P97	33.9102
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.L1017M (No)	GDSC	JAK3_7406	13.8983
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.L1017M (No)	GDSC	AZ960	1.4228
SIDM01032	ESCA\|oesophagus	p.V469L (No)	GDSC	WHI-P97	4.7889
SIDM01032	ESCA\|oesophagus	p.V469L (No)	GDSC	JAK3_7406	55.0416
SIDM01032	ESCA\|oesophagus	p.V469L (No)	GDSC	AZ960	12.018
SIDM00455	PAAD\|pancreas	p.R121H (No)	GDSC	WHI-P97	34.3675
SIDM00455	PAAD\|pancreas	p.R121H (No)	GDSC	JAK3_7406	7.4783
SIDM00455	PAAD\|pancreas	p.R121H (No)	GDSC	AZ960	43.757
SIDM00661	DLBC\|B_cell_lymphoma	p.P151R (No)	GDSC	WHI-P97	42.6384
SIDM00661	DLBC\|B_cell_lymphoma	p.P151R (No)	GDSC	JAK3_7406	38.0631
SIDM00081	SKCM\|melanoma	p.P693L (No)	GDSC	WHI-P97	40.7542
SIDM00081	SKCM\|melanoma	p.P693L (No)	GDSC	JAK3_7406	61.1796
SIDM00382	GBM\|glioma	p.I991V (No)	GDSC	WHI-P97	60.0632
SIDM00382	GBM\|glioma	p.I991V (No)	GDSC	JAK3_7406	19.9325
SIDM00214	COREAD\|large_intestine	p.E997fs*45 (No)	GDSC	WHI-P97	22.8025
SIDM00214	COREAD\|large_intestine	p.E997fs*45 (No)	GDSC	JAK3_7406	7.1724
SIDM00214	COREAD\|large_intestine	p.E997fs*45 (No)	GDSC	AZ960	55.128
SIDM01007	ALL\|lymphoblastic_leukemia	p.P672H (No)	GDSC	WHI-P97	38.4311
SIDM01007	ALL\|lymphoblastic_leukemia	p.P672H (No)	GDSC	JAK3_7406	87.4136
SIDM01007	ALL\|lymphoblastic_leukemia	p.P672H (No)	GDSC	AZ960	1.7309
SIDM00142	UCEC\|endometrium	p.K830M (No)	GDSC	WHI-P97	98.2843
SIDM00142	UCEC\|endometrium	p.K830M (No)	GDSC	JAK3_7406	113.8295
SIDM00142	UCEC\|endometrium	p.K830M (No)	GDSC	AZ960	14.199
SIDM01106	SKCM\|melanoma	p.L1073I (No)	GDSC	WHI-P97	32.2712
SIDM01106	SKCM\|melanoma	p.L1073I (No)	GDSC	JAK3_7406	71.569
SIDM01106	SKCM\|melanoma	p.L1073I (No)	GDSC	AZ960	25.045
SIDM00633	BRCA\|breast	p.H879R (No)	GDSC	WHI-P97	25.4726
SIDM00633	BRCA\|breast	p.H879R (No)	GDSC	JAK3_7406	75.9574
SIDM00041	UNCLASSIFIED\|soft_tissue_other	p.P151R (No)	GDSC	JAK3_7406	14.8112
SIDM00887	MB\|medulloblastoma	p.T321N (No)	GDSC	WHI-P97	45.7842
SIDM00887	MB\|medulloblastoma	p.T321N (No)	GDSC	JAK3_7406	10.8486
SIDM00887	MB\|medulloblastoma	p.T321N (No)	GDSC	AZ960	2.0104
SIDM00498	COREAD\|large_intestine	p.V1016D (No)	GDSC	WHI-P97	119.1519
SIDM00498	COREAD\|large_intestine	p.V1016D (No)	GDSC	JAK3_7406	22.6592
SIDM00498	COREAD\|large_intestine	p.V1016D (No)	GDSC	AZ960	8.5553
SIDM00982	GBM\|glioma	p.P151R (No)	GDSC	WHI-P97	98.0259
SIDM00982	GBM\|glioma	p.P151R (No)	GDSC	JAK3_7406	6.9159
SIDM00982	GBM\|glioma	p.P151R (No)	GDSC	AZ960	2.9204
SIDM00988	KIRC\|kidney	p.F82S (No)	GDSC	WHI-P97	68.9244
SIDM00988	KIRC\|kidney	p.F82S (No)	GDSC	JAK3_7406	39.9296
SIDM00988	KIRC\|kidney	p.F82S (No)	GDSC	AZ960	3.5098
SIDM00668	UNCLASSIFIED\|Hodgkin_lymphoma	p.V722I (No)	GDSC	WHI-P97	33.6003
SIDM00668	UNCLASSIFIED\|Hodgkin_lymphoma	p.V722I (No)	GDSC	JAK3_7406	23.4413
SIDM00668	UNCLASSIFIED\|Hodgkin_lymphoma	p.V722I (No)	GDSC	AZ960	19.64
SIDM00668	UNCLASSIFIED\|Hodgkin_lymphoma	p.P151R (No)	GDSC	WHI-P97	33.6003
SIDM00668	UNCLASSIFIED\|Hodgkin_lymphoma	p.P151R (No)	GDSC	JAK3_7406	23.4413
SIDM00668	UNCLASSIFIED\|Hodgkin_lymphoma	p.P151R (No)	GDSC	AZ960	19.64
SIDM00475	OV\|ovary	p.F82S (No)	GDSC	WHI-P97	42.1493
SIDM00475	OV\|ovary	p.F82S (No)	GDSC	JAK3_7406	26.8543
SIDM00475	OV\|ovary	p.F82S (No)	GDSC	AZ960	66.447
SIDM00156	NB\|neuroblastoma	p.F82S (No)	GDSC	WHI-P97	61.3968
SIDM00156	NB\|neuroblastoma	p.F82S (No)	GDSC	JAK3_7406	24.4564
SIDM00156	NB\|neuroblastoma	p.F82S (No)	GDSC	AZ960	5.883
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E698K (No)	GDSC	WHI-P97	169.3662
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E698K (No)	GDSC	JAK3_7406	13.3166
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E698K (No)	GDSC	AZ960	33.458
SIDM00864	CESC\|cervix	p.S504C (Yes)	GDSC	WHI-P97	12.5734
SIDM00864	CESC\|cervix	p.S504C (Yes)	GDSC	JAK3_7406	9.7393
SIDM00864	CESC\|cervix	p.S504C (Yes)	GDSC	AZ960	1.9184
SIDM00476	OV\|ovary	p.F82S (No)	GDSC	WHI-P97	257.9599
SIDM00476	OV\|ovary	p.F82S (No)	GDSC	JAK3_7406	100.6343
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.H645Y (No)	GDSC	WHI-P97	111.4133
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.H645Y (No)	GDSC	JAK3_7406	8.2428
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.H645Y (No)	GDSC	AZ960	4.3684
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.A1079D (No)	GDSC	WHI-P97	7.6764
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.A1079D (No)	GDSC	JAK3_7406	15.4604
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.A1079D (No)	GDSC	AZ960	7.8944
SIDM00217	COREAD\|large_intestine	p.R403H (No)	GDSC	WHI-P97	7.6631
SIDM00217	COREAD\|large_intestine	p.R403H (No)	GDSC	JAK3_7406	167.9476
SIDM00217	COREAD\|large_intestine	p.R403H (No)	GDSC	AZ960	81.595
SIDM01165	PAAD\|pancreas	p.Q510R (No)	GDSC	WHI-P97	143.2994
SIDM01165	PAAD\|pancreas	p.Q510R (No)	GDSC	JAK3_7406	202.4877
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A660fs*10 (No)	GDSC	WHI-P97	25.4854
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A660fs*10 (No)	GDSC	JAK3_7406	22.8808
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A660fs*10 (No)	GDSC	AZ960	0.3917
SIDM00282	COREAD\|large_intestine	p.V957M (No)	GDSC	WHI-P97	241.7135
SIDM00282	COREAD\|large_intestine	p.V957M (No)	GDSC	JAK3_7406	185.4099
SIDM00282	COREAD\|large_intestine	p.V957M (No)	GDSC	AZ960	59.862
SIDM01057	LAML\|acute_myeloid_leukaemia	p.V722I (No)	GDSC	WHI-P97	16.5395
SIDM01057	LAML\|acute_myeloid_leukaemia	p.V722I (No)	GDSC	JAK3_7406	9.3265
SIDM01057	LAML\|acute_myeloid_leukaemia	p.V722I (No)	GDSC	AZ960	0.5141
SIDM01057	LAML\|acute_myeloid_leukaemia	p.P151R (No)	GDSC	WHI-P97	16.5395
SIDM01057	LAML\|acute_myeloid_leukaemia	p.P151R (No)	GDSC	JAK3_7406	9.3265
SIDM01057	LAML\|acute_myeloid_leukaemia	p.P151R (No)	GDSC	AZ960	0.5141
SIDM00685	GBM\|glioma	p.W803S (No)	GDSC	WHI-P97	68.9013
SIDM00685	GBM\|glioma	p.W803S (No)	GDSC	JAK3_7406	64.7849
SIDM00685	GBM\|glioma	p.W803S (No)	GDSC	AZ960	8.6051
SIDM00637	DLBC\|B_cell_lymphoma	p.F82S (No)	GDSC	WHI-P97	31.4773
SIDM00637	DLBC\|B_cell_lymphoma	p.F82S (No)	GDSC	JAK3_7406	10.6602
SIDM00660	COREAD\|large_intestine	p.L605M (No)	GDSC	WHI-P97	169.4305
SIDM00660	COREAD\|large_intestine	p.L605M (No)	GDSC	JAK3_7406	45.0713
SIDM00660	COREAD\|large_intestine	p.L605M (No)	GDSC	AZ960	16.765
SIDM00882	BRCA\|breast	p.R395C (No)	GDSC	WHI-P97	91.9187
SIDM00882	BRCA\|breast	p.R395C (No)	GDSC	JAK3_7406	96.3246
SIDM00882	BRCA\|breast	p.R395C (No)	GDSC	AZ960	189.32
SIDM01147	STAD\|stomach	p.A1090T (No)	GDSC	JAK3_7406	237.4099
SIDM01147	STAD\|stomach	p.A1090T (No)	GDSC	AZ960	37.231
SIDM00501	HNSC\|head_and_neck	p.D740Y (No)	GDSC	WHI-P97	143.7019
SIDM00501	HNSC\|head_and_neck	p.D740Y (No)	GDSC	JAK3_7406	17.4134
SIDM00501	HNSC\|head_and_neck	p.D740Y (No)	GDSC	AZ960	136
SIDM00458	LAML\|acute_myeloid_leukaemia	p.R180Q (No)	GDSC	WHI-P97	16.8656
SIDM00458	LAML\|acute_myeloid_leukaemia	p.R180Q (No)	GDSC	JAK3_7406	41.4658
SIDM00458	LAML\|acute_myeloid_leukaemia	p.R180Q (No)	GDSC	AZ960	0.3503
SIDM00458	LAML\|acute_myeloid_leukaemia	p.P151R (No)	GDSC	WHI-P97	16.8656
SIDM00458	LAML\|acute_myeloid_leukaemia	p.P151R (No)	GDSC	JAK3_7406	41.4658
SIDM00458	LAML\|acute_myeloid_leukaemia	p.P151R (No)	GDSC	AZ960	0.3503
SIDM01205	DLBC\|B_cell_lymphoma	p.M511I (No)	GDSC	WHI-P97	43.9638
SIDM01205	DLBC\|B_cell_lymphoma	p.M511I (No)	GDSC	JAK3_7406	0.686
SIDM01205	DLBC\|B_cell_lymphoma	p.M511I (No)	GDSC	AZ960	0.7121
SIDM00789	COREAD\|large_intestine	p.H1113R (No)	GDSC	WHI-P97	89.2948
SIDM00789	COREAD\|large_intestine	p.H1113R (No)	GDSC	JAK3_7406	88.6554
SIDM00789	COREAD\|large_intestine	p.H1113R (No)	GDSC	AZ960	1.4145
SIDM00789	COREAD\|large_intestine	p.V963I (No)	GDSC	WHI-P97	89.2948
SIDM00789	COREAD\|large_intestine	p.V963I (No)	GDSC	JAK3_7406	88.6554
SIDM00789	COREAD\|large_intestine	p.V963I (No)	GDSC	AZ960	1.4145
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E1072K (No)	GDSC	WHI-P97	430.9241
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E1072K (No)	GDSC	JAK3_7406	198.1983
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E1072K (No)	GDSC	AZ960	126.95
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P423L (No)	GDSC	WHI-P97	430.9241
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P423L (No)	GDSC	JAK3_7406	198.1983
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P423L (No)	GDSC	AZ960	126.95
SIDM00487	COREAD\|large_intestine	p.P37A (No)	GDSC	WHI-P97	7.5998
SIDM00487	COREAD\|large_intestine	p.P37A (No)	GDSC	JAK3_7406	200.3468
SIDM00487	COREAD\|large_intestine	p.P37A (No)	GDSC	AZ960	28.774
SIDM01087	SKCM\|melanoma	p.H645Y (No)	GDSC	WHI-P97	118.3178
SIDM01087	SKCM\|melanoma	p.H645Y (No)	GDSC	JAK3_7406	11.4153
SIDM01087	SKCM\|melanoma	p.H645Y (No)	GDSC	AZ960	2.9781
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R403H (No)	GDSC	WHI-P97	34.4594
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R403H (No)	GDSC	JAK3_7406	96.0362
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R403H (No)	GDSC	AZ960	2.8096
SIDM00992	THCA\|thyroid	p.N108S (No)	GDSC	WHI-P97	84.1226
SIDM00992	THCA\|thyroid	p.N108S (No)	GDSC	JAK3_7406	15.6286
SIDM00992	THCA\|thyroid	p.N108S (No)	GDSC	AZ960	7.2098
SIDM01259	ALL\|lymphoblastic_leukemia	p.M598T (No)	GDSC	WHI-P97	31.1613
SIDM01259	ALL\|lymphoblastic_leukemia	p.M598T (No)	GDSC	JAK3_7406	22.6017
SIDM01259	ALL\|lymphoblastic_leukemia	p.M598T (No)	GDSC	AZ960	12.713
SIDM00537	COREAD\|large_intestine	p.H315R (No)	GDSC	WHI-P97	13.3088
SIDM00537	COREAD\|large_intestine	p.H315R (No)	GDSC	JAK3_7406	80.1629
SIDM00537	COREAD\|large_intestine	p.H315R (No)	GDSC	AZ960	1.9303
SIDM00684	GBM\|glioma	p.M1097L (No)	GDSC	WHI-P97	51.8683
SIDM00684	GBM\|glioma	p.M1097L (No)	GDSC	JAK3_7406	31.7802
SIDM00684	GBM\|glioma	p.M1097L (No)	GDSC	AZ960	47.482
SIDM00878	BRCA\|breast	p.F71L (No)	GDSC	WHI-P97	67.2193
SIDM00878	BRCA\|breast	p.F71L (No)	GDSC	JAK3_7406	93.9448
SIDM00878	BRCA\|breast	p.F71L (No)	GDSC	AZ960	3.5155
SIDM00679	CESC\|cervix	p.E1115K (No)	GDSC	WHI-P97	37.6586
SIDM00679	CESC\|cervix	p.E1115K (No)	GDSC	JAK3_7406	13.5291
SIDM00679	CESC\|cervix	p.E1115K (No)	GDSC	AZ960	30.262
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.G153S (No)	GDSC	WHI-P97	208.671
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.G153S (No)	GDSC	JAK3_7406	83.714

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14773	Tripeptidyl-peptidase 1	DEG_SPOP_SBC_1	177:181	PPTSS	SPOP	0.9584	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	340:344	PPTSS	SPOP	0.6236	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	819:823	PPTSS	SPOP	0.9708	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	176:180	PPTSS	SPOP	0.6895	More...
P52333	Tyrosine-protein kinase JAK3	DEG_SPOP_SBC_1	494:498	PPTSS	SPOP	0.8529	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3890:3894	PPTSS	SPOP	0.5277	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	368:372	PPTSS	SPOP	0.8864	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1119:1123	PPTSS	SPOP	0.925	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1496:1500	PPTSS	SPOP	0.9496	More...
Q15311	RalA-binding protein 1	DEG_SPOP_SBC_1	7:11	PPTSS	SPOP	0.9992	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1228:1232	PPTSS	SPOP	0.9477	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	567:571	PPTSS	SPOP	0.9694	More...
Q8TCX5	Rhophilin-1	DEG_SPOP_SBC_1	384:388	PPTSS	SPOP	0.7809	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	336:340	PPTSS	SPOP	0.7185	More...
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_SPOP_SBC_1	45:49	PPTSS	SPOP	0.9468	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	572:576	PPTSS	SPOP	0.9415	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	512:516	PPTSS	SPOP	0.8871	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	141:145	PPTSS	SPOP	0.9976	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	1600:1604	PPTSS	SPOP	0.9908	More...
Q9NT68	Teneurin-2	DEG_SPOP_SBC_1	172:176	PPTSS	SPOP	0.9859	More...
Q6P499	NIPA-like protein 3	DEG_SPOP_SBC_1	15:19	PPTSS	SPOP	0.8666	More...
Q8N801	Protein STPG4	DEG_SPOP_SBC_1	187:191	PPTSS	SPOP	0.5486	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	705:709	PPTSS	SPOP	0.8542	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	727:731	PPTSS	SPOP	0.971	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	936:940	PPTSS	SPOP	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTSS

Degron related mutations and impact score

Drug responses associated with JAK3 mutations

All proteins holding degron of PPTSS