DegronMD - Q96DN6(MBD6)

FUNCTION: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).

GO - Biological processes (BP):

GO - Molecular function (MF): chromatin binding [GO:0003682]

GO - Cellular component (CC): chromocenter [GO:0010369]; chromosome [GO:0005694]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P589L	DO27817	MALY	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.7582
p.S387I	DO229037	LICA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation altering degron motif	0.7341
p.S466N	TCGA-AA-A00N	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S466N	DO9876	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S466N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S466N	ACH-002222	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S466N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S709N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7069
p.S709N	ACH-001127	Leukemia	CCLE	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7069
p.S709N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7069
p.P589T	TCGA-DA-A1I1	SKCM	TCGA	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.7031
p.P589T	DO37966	SKCM	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.7031
p.P462T	SIDM00213	Thyroid Gland Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7031
p.P462T	ACH-000903	Thyroid Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7031
p.P462T	FTC-133	thyroid	COSMIC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7031
p.P829H	SIDM02050	Colorectal Carcinoma	GDSC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation altering degron motif	0.6583
p.R386Q	DO220883	MELA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation altering degron motif	0.6218
p.P592T	TCGA-FI-A2F4	UCEC	TCGA	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.5919
p.P592T	DO43434	UCEC	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.5919
p.R388H	TCGA-DM-A280	COAD	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 105 entries

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Kaplan plot for MBD6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MBD6

UniProt ID: Q96DN6

Entrez ID: 114785

Protein name: Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MBD6 in