DegronMD - Q96DN6(MBD6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E377Q	TCGA-21-5783	LUSC	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.2222
p.E377Q	DO27437	LUSC	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.2222
p.R390Q	TCGA-2W-A8YY	CESC	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.R390Q	DO223732	CESC	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.R390Q	SIDM00282	Colorectal Carcinoma	GDSC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.R390Q	ACH-000998	Colon/Colorectal Cancer	CCLE	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.R390Q	CW-2	large intestine	COSMIC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.P453H	TCGA-86-A4JF	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.0833
p.P453H	DO45317	LUAD	ICGC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.0833
p.S466N	TCGA-AA-A00N	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S466N	DO9876	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S466N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S466N	ACH-002222	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.S466N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7069
p.A719T	TCGA-AA-A010	COAD	TCGA	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.0556
p.S820P	TCGA-AD-6895	COAD	TCGA	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.1389
p.S820P	TCGA-DA-A95X	SKCM	TCGA	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.1389
p.S820P	DO8938	COAD	ICGC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.1389
p.S820P	DO219480	SKCM	ICGC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.1389
p.A87T	TCGA-AP-A1DK	UCEC	TCGA	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.2778
p.A87T	DO42033	UCEC	ICGC	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.2778
p.G378E	TCGA-AP-A1DK	UCEC	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.G378E	DO42033	UCEC	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.T712M	TCGA-AP-A1DM	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.25
p.T712M	DO43106	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.25
p.T712M	SIDM01139	Pancreatic Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.25
p.T712M	PANC-02-03	pancreas	COSMIC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.25
p.S411Y	TCGA-AX-A06F	UCEC	TCGA	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1389
p.S411Y	DO41752	UCEC	ICGC	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1389
p.R857W	TCGA-BR-A4QL	STAD	TCGA	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.0833
p.R857W	DO38723	STAD	ICGC	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.0833
p.P589T	TCGA-DA-A1I1	SKCM	TCGA	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.7031
p.P589T	DO37966	SKCM	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.7031
p.P67S	TCGA-DK-A2I6	BLCA	TCGA	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.0556
p.P67S	DO798	BLCA	ICGC	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.0556
p.P67L	TCGA-DK-A2I6	BLCA	TCGA	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.0556
p.P67L	DO798	BLCA	ICGC	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.0556
p.R388H	TCGA-DM-A280	COAD	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.3056
p.R388H	DO8256	COAD	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.3056
p.S426C	TCGA-DS-A7WH	CESC	TCGA	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.2778
p.S426C	DO48422	BLCA	ICGC	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.2778
p.S426C	DO49923	CESC	ICGC	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.2778
p.P389H	TCGA-DU-6392	LGG	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.2778
p.P389H	DO22237	LGG	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.2778
p.N75K	TCGA-E2-A105	BRCA	TCGA	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.2778
p.N75K	DO3536	BRCA	ICGC	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.2778
p.G378R	TCGA-EE-A29E	SKCM	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.G378R	DO37831	SKCM	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.25
p.R857L	TCGA-EE-A29L	SKCM	TCGA	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.0833
p.R857L	DO37835	SKCM	ICGC	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.0833
p.G380R	TCGA-FD-A3N5	BLCA	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.3056
p.G380R	DO639	BLCA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.3056
p.P592T	TCGA-FI-A2F4	UCEC	TCGA	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.5919
p.P592T	DO43434	UCEC	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.5919
p.R374Q	TCGA-JW-A5VL	CESC	TCGA	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.1389
p.R374Q	DO49976	CESC	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.1389
p.S93L	TCGA-QK-A6VC	HNSC	TCGA	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.1111
p.S93L	DO219056	HNSC	ICGC	DPLAPVTPG	DEG_SIAH_1	77:85	Mutation rewiring degron network	0.1111
p.P818L	TCGA-YD-A9TA	SKCM	TCGA	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.0833
p.P818L	DO219503	SKCM	ICGC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.0833
p.E823K	DO228123	EOPC	ICGC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2222
p.A700V	DO234272	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.V697F	DO228900	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1111
p.R852S	DO228902	LICA	ICGC	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.2222
p.R388L	DO228976	LICA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.3056
p.S387I	DO229037	LICA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation altering degron motif	0.7341
p.P589L	DO27817	MALY	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	587:599	Mutation altering degron motif	0.7582
p.R386Q	DO220883	MELA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation altering degron motif	0.6218
p.R388C	DO51541	PACA	ICGC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.3056
p.P829H	SIDM02050	Colorectal Carcinoma	GDSC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation altering degron motif	0.6583
p.G855W	SIDM00683	Prostate Carcinoma	GDSC	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.1389
p.G855W	ACH-000977	lymph node	CCLE	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.1389
p.S471N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1944
p.S471N	ACH-000981	Leukemia	CCLE	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1944
p.S471N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1944
p.G839A	SIDM00845	Burkitt's Lymphoma	GDSC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2222
p.G839A	SIDM00845	Burkitt's Lymphoma	GDSC	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.3056
p.G839A	ACH-000786	Lymphoma	CCLE	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2222
p.G839A	ACH-000786	Lymphoma	CCLE	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.3056
p.P410L	SIDM00660	Colorectal Carcinoma	GDSC	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1111
p.P410L	ACH-000985	Colon/Colorectal Cancer	CCLE	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1111
p.P410L	LS-411N	large intestine	COSMIC	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.1111
p.T714A	SIDM01149	Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.T714A	ACH-001365	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.T714A	NCI-H847	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1944
p.S460C	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.2778
p.S460C	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.2778
p.P389S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.2778
p.P837L	SIDM00560	Gastric Carcinoma	GDSC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2778
p.P837L	SIDM00560	Gastric Carcinoma	GDSC	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.25
p.P837L	ACH-000678	Gastric Cancer	CCLE	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2778
p.P837L	ACH-000678	Gastric Cancer	CCLE	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.25
p.P837L	MKN7	stomach	COSMIC	ARPPLSALA	DEG_APCC_DBOX_1	827:835	Mutation rewiring degron network	0.2778
p.P837L	MKN7	stomach	COSMIC	SPDPPVPEL	DEG_COP1_1	840:848	Mutation rewiring degron network	0.25
p.A713T	SIDM00217	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.2222
p.A713T	ACH-000999	Colon/Colorectal Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.2222
p.A713T	SNU-1040	large intestine	COSMIC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.2222
p.S709N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7069
p.S709N	ACH-001127	Leukemia	CCLE	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7069
p.S709N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7069
p.P462T	SIDM00213	Thyroid Gland Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7031
p.P462T	ACH-000903	Thyroid Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7031
p.P462T	FTC-133	thyroid	COSMIC	PGTTS	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7031
p.G380D	ACH-001524	Skin Cancer	CCLE	PQTPRRS	DEG_SCF_FBW7_1	381:387	Mutation rewiring degron network	0.3056
p.S414F	ACH-001550	Skin Cancer	CCLE	LPTPGPS	DEG_SCF_FBW7_1	418:424	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MBD6

UniProt ID: Q96DN6

Entrez ID: 114785

Protein name: Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MBD6 in