DegronMD

Uniprot ID: Q96DN6

Source protein: Methyl-CpG-binding domain protein 6

Source gene: MBD6

Class: DEG_SCF_FBW7_1

Location: 418:424

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 80.1

COIL: 0.9657

CONS_SCORE: 0.4395

DSS_SCORE: 0.5057

HELIX: 0.0116

FCONS_SCORE: 1.1111

RIG_SCORE: 0.547

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S426C	TCGA-DS-A7WH	CESC	TCGA	LPTPGPS	DEG_SCF_FBW7_1	0.2778
p.S426C	DO48422	BLCA	ICGC	LPTPGPS	DEG_SCF_FBW7_1	0.2778
p.S426C	DO49923	CESC	ICGC	LPTPGPS	DEG_SCF_FBW7_1	0.2778
p.S414F	ACH-001550	Skin Cancer	CCLE	LPTPGPS	DEG_SCF_FBW7_1	0.2222
p.S411Y	TCGA-AX-A06F	UCEC	TCGA	LPTPGPS	DEG_SCF_FBW7_1	0.1389
p.S411Y	DO41752	UCEC	ICGC	LPTPGPS	DEG_SCF_FBW7_1	0.1389
p.P410L	SIDM00660	Colorectal Carcinoma	GDSC	LPTPGPS	DEG_SCF_FBW7_1	0.1111
p.P410L	ACH-000985	Colon/Colorectal Cancer	CCLE	LPTPGPS	DEG_SCF_FBW7_1	0.1111
p.P410L	LS-411N	large_intestine	COSMIC	LPTPGPS	DEG_SCF_FBW7_1	0.1111

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SCF_FBW7_1	418:424	LPTPGPS	FBXW7	0.9915	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons