DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LPTPGPS
Uniprot ID:
Q96DN6
Source protein:
Methyl-CpG-binding domain protein 6
Source gene:
MBD6
Class:
DEG_SCF_FBW7_1
Location:
418:424
E3 ligase:
FBXW7
DEGRON score:
0.9915
ASA_SCORE:
80.1
COIL:
0.9657
CONS_SCORE:
0.4395
DSS_SCORE:
0.5057
HELIX:
0.0116
FCONS_SCORE:
1.1111
RIG_SCORE:
0.547
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S411Y
TCGA-AX-A06F
UCEC
TCGA
LPTPGPS
DEG_SCF_FBW7_1
0.1389
p.S411Y
DO41752
UCEC
ICGC
LPTPGPS
DEG_SCF_FBW7_1
0.1389
p.S426C
TCGA-DS-A7WH
CESC
TCGA
LPTPGPS
DEG_SCF_FBW7_1
0.2778
p.S426C
DO48422
BLCA
ICGC
LPTPGPS
DEG_SCF_FBW7_1
0.2778
p.S426C
DO49923
CESC
ICGC
LPTPGPS
DEG_SCF_FBW7_1
0.2778
p.P410L
SIDM00660
Colorectal Carcinoma
GDSC
LPTPGPS
DEG_SCF_FBW7_1
0.1111
p.P410L
ACH-000985
Colon/Colorectal Cancer
CCLE
LPTPGPS
DEG_SCF_FBW7_1
0.1111
p.P410L
LS-411N
large_intestine
COSMIC
LPTPGPS
DEG_SCF_FBW7_1
0.1111
p.S414F
ACH-001550
Skin Cancer
CCLE
LPTPGPS
DEG_SCF_FBW7_1
0.2222
Drug responses associated with MBD6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPTPGPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96DN6
Methyl-CpG-binding domain protein 6
DEG_SCF_FBW7_1
418:424
LPTPGPS
FBXW7
0.9915
More...