DegronMD

Uniprot ID: Q96DN6

Source protein: Methyl-CpG-binding domain protein 6

Source gene: MBD6

Class: DEG_SIAH_1

Location: 77:85

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9656

ASA_SCORE: 56.1333

COIL: 0.7313

CONS_SCORE: 0.5593

DSS_SCORE: 0.3262

HELIX: 0.0392

FCONS_SCORE: 0.9926

RIG_SCORE: 0.7373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A87T	TCGA-AP-A1DK	UCEC	TCGA	DPLAPVTPG	DEG_SIAH_1	0.2778
p.A87T	DO42033	UCEC	ICGC	DPLAPVTPG	DEG_SIAH_1	0.2778
p.P67S	TCGA-DK-A2I6	BLCA	TCGA	DPLAPVTPG	DEG_SIAH_1	0.0556
p.P67S	DO798	BLCA	ICGC	DPLAPVTPG	DEG_SIAH_1	0.0556
p.P67L	TCGA-DK-A2I6	BLCA	TCGA	DPLAPVTPG	DEG_SIAH_1	0.0556
p.P67L	DO798	BLCA	ICGC	DPLAPVTPG	DEG_SIAH_1	0.0556
p.N75K	TCGA-E2-A105	BRCA	TCGA	DPLAPVTPG	DEG_SIAH_1	0.2778
p.N75K	DO3536	BRCA	ICGC	DPLAPVTPG	DEG_SIAH_1	0.2778
p.S93L	TCGA-QK-A6VC	HNSC	TCGA	DPLAPVTPG	DEG_SIAH_1	0.1111
p.S93L	DO219056	HNSC	ICGC	DPLAPVTPG	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SIAH_1	77:85	DPLAPVTPG	SIAH1,SIAH2,SIAH3	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons