DegronMD

Uniprot ID: Q96DN6

Source protein: Methyl-CpG-binding domain protein 6

Source gene: MBD6

Class: DEG_COP1_1

Location: 840:848

E3 ligase: COP1

DEGRON score: 0.5066

ASA_SCORE: 91.5778

COIL: 0.9327

CONS_SCORE: 0.4322

DSS_SCORE: 0.7889

HELIX: 0.0489

FCONS_SCORE: 1.0148

RIG_SCORE: 0.5884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R857W	TCGA-BR-A4QL	STAD	TCGA	SPDPPVPEL	DEG_COP1_1	0.0833
p.R857W	DO38723	STAD	ICGC	SPDPPVPEL	DEG_COP1_1	0.0833
p.R857L	TCGA-EE-A29L	SKCM	TCGA	SPDPPVPEL	DEG_COP1_1	0.0833
p.R857L	DO37835	SKCM	ICGC	SPDPPVPEL	DEG_COP1_1	0.0833
p.R852S	DO228902	LICA	ICGC	SPDPPVPEL	DEG_COP1_1	0.2222
p.G855W	SIDM00683	Prostate Carcinoma	GDSC	SPDPPVPEL	DEG_COP1_1	0.1389
p.G855W	ACH-000977	lymph_node	CCLE	SPDPPVPEL	DEG_COP1_1	0.1389
p.G839A	SIDM00845	Burkitt's Lymphoma	GDSC	SPDPPVPEL	DEG_COP1_1	0.3056
p.G839A	ACH-000786	Lymphoma	CCLE	SPDPPVPEL	DEG_COP1_1	0.3056
p.P837L	SIDM00560	Gastric Carcinoma	GDSC	SPDPPVPEL	DEG_COP1_1	0.25
p.P837L	ACH-000678	Gastric Cancer	CCLE	SPDPPVPEL	DEG_COP1_1	0.25
p.P837L	MKN7	stomach	COSMIC	SPDPPVPEL	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_COP1_1	840:848	SPDPPVPEL	COP1	0.5066	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons