DegronMD

Uniprot ID: Q96DN6

Source protein: Methyl-CpG-binding domain protein 6

Source gene: MBD6

Class: DEG_APCC_DBOX_1

Location: 827:835

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7751

ASA_SCORE: 90.9667

COIL: 0.9507

CONS_SCORE: 0.3984

DSS_SCORE: 0.773

HELIX: 0.0288

FCONS_SCORE: 0.9629

RIG_SCORE: 0.5466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S820P	TCGA-AD-6895	COAD	TCGA	ARPPLSALA	DEG_APCC_DBOX_1	0.1389
p.S820P	TCGA-DA-A95X	SKCM	TCGA	ARPPLSALA	DEG_APCC_DBOX_1	0.1389
p.S820P	DO8938	COAD	ICGC	ARPPLSALA	DEG_APCC_DBOX_1	0.1389
p.S820P	DO219480	SKCM	ICGC	ARPPLSALA	DEG_APCC_DBOX_1	0.1389
p.P818L	TCGA-YD-A9TA	SKCM	TCGA	ARPPLSALA	DEG_APCC_DBOX_1	0.0833
p.P818L	DO219503	SKCM	ICGC	ARPPLSALA	DEG_APCC_DBOX_1	0.0833
p.E823K	DO228123	EOPC	ICGC	ARPPLSALA	DEG_APCC_DBOX_1	0.2222
p.P829H	SIDM02050	Colorectal Carcinoma	GDSC	ARPPLSALA	DEG_APCC_DBOX_1	0.6583
p.G839A	SIDM00845	Burkitt's Lymphoma	GDSC	ARPPLSALA	DEG_APCC_DBOX_1	0.2222
p.G839A	ACH-000786	Lymphoma	CCLE	ARPPLSALA	DEG_APCC_DBOX_1	0.2222
p.P837L	SIDM00560	Gastric Carcinoma	GDSC	ARPPLSALA	DEG_APCC_DBOX_1	0.2778
p.P837L	ACH-000678	Gastric Cancer	CCLE	ARPPLSALA	DEG_APCC_DBOX_1	0.2778
p.P837L	MKN7	stomach	COSMIC	ARPPLSALA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_APCC_DBOX_1	827:835	ARPPLSALA	APC,CDC20,FZR1	0.7751	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons