DegronMD

Uniprot ID: Q96DN6

Source protein: Methyl-CpG-binding domain protein 6

Source gene: MBD6

Class: DEG_ODPH_VHL_1

Location: 587:599

E3 ligase: VHL

DEGRON score: 0.5785

ASA_SCORE: 89.6

COIL: 0.949

CONS_SCORE: 0.4129

DSS_SCORE: 0.6981

HELIX: 0.0274

FCONS_SCORE: 0.9642

RIG_SCORE: 0.565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P589T	TCGA-DA-A1I1	SKCM	TCGA	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	0.7031
p.P589T	DO37966	SKCM	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	0.7031
p.P592T	TCGA-FI-A2F4	UCEC	TCGA	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	0.5919
p.P592T	DO43434	UCEC	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	0.5919
p.P589L	DO27817	MALY	ICGC	LAPGEPEGPSLLV	DEG_ODPH_VHL_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_ODPH_VHL_1	587:599	LAPGEPEGPSLLV	VHL	0.5785	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons